• Product nameAnti-Factor I antibody
    See all Factor I primary antibodies
  • Description
    Mouse polyclonal to Factor I
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Full length protein, corresponding to amino acids 1 - 377 of Human Factor I mature form (AAH20718.1).

  • Positive control
    • Kidney lysate


  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage bufferPreservative: None
    Constituents: PBS, pH 7.2
  • Concentration information loading...
  • PurityProtein A purified
  • ClonalityPolyclonal
  • IsotypeIgG
  • Research areas

Associated products


Our Abpromise guarantee covers the use of ab90546 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
  • Application notesWB: Use at a concentration of 1 µg/ml. Predicted molecular weight: 65 kDa (unprocessed precursor).

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionResponsible for cleaving the alpha-chains of C4b and C3b in the presence of the cofactors C4-binding protein and factor H respectively.
    • Tissue specificityPlasma.
    • Involvement in diseaseDefects in CFI are a cause of susceptibility to hemolytic uremic syndrome atypical type 3 (AHUS3) [MIM:612923]. An atypical form of hemolytic uremic syndrome. It is a complex genetic disease characterized by microangiopathic hemolytic anemia, thrombocytopenia, renal failure and absence of episodes of enterocolitis and diarrhea. In contrast to typical hemolytic uremic syndrome, atypical forms have a poorer prognosis, with higher death rates and frequent progression to end-stage renal disease. Note=Susceptibility to the development of atypical hemolytic uremic syndrome can be conferred by mutations in various components of or regulatory factors in the complement cascade system. Other genes may play a role in modifying the phenotype.
      Defects in CFI are the cause of complement factor I deficiency (CFI deficiency) [MIM:610984]. CFI deficiency is an autosomal recessive condition associated with a propensity to pyogenic infections.
    • Sequence similaritiesBelongs to the peptidase S1 family.
      Contains 1 Kazal-like domain.
      Contains 2 LDL-receptor class A domains.
      Contains 1 peptidase S1 domain.
      Contains 1 SRCR domain.
    • Cellular localizationSecreted > extracellular space.
    • Information by UniProt
    • Database links
    • Alternative names
      • AHUS3 antibody
      • ARMD13 antibody
      • C3b INA antibody
      • C3b inactivator antibody
      • C3B/C4B inactivator antibody
      • C3BINA antibody
      • CFAI_HUMAN antibody
      • Cfi antibody
      • Complement component I antibody
      • Complement control protein factor I antibody
      • Complement factor I antibody
      • Complement factor I heavy chain antibody
      • Complement factor I light chain antibody
      • F1 antibody
      • factor I antibody
      • FactorI antibody
      • FI antibody
      • I factor antibody
      • IF antibody
      • KAF antibody
      • Konglutinogen activating factor antibody
      • Light chain of factor I antibody
      • OTTHUMP00000219728 antibody
      • OTTHUMP00000221928 antibody
      see all

    Anti-Factor I antibody images

    • Anti-Factor I antibody (ab90546) at 1 µg/ml + Human kidney lysate at 50 µg

      Predicted band size : 65 kDa
    • All lanes : Anti-Factor I antibody (ab90546) at 1 µg/ml

      Lane 1 : Factor I-transfected 293T cell lysate
      Lane 2 : non transfected lysate

      Lysates/proteins at 25 µg per lane.

      Predicted band size : 65 kDa

    References for Anti-Factor I antibody (ab90546)

    ab90546 has not yet been referenced specifically in any publications.

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    There are currently no Abreviews or Questions for ab90546.
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