Overview

  • Product name
  • Description
    Rabbit polyclonal to Factor IX
  • Host species
    Rabbit
  • Tested applications
    Suitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    Recombinant full length protein corresponding to Human Factor IX.
    Database link: P00740

  • Positive control
    • Extracts of HO-8910 cell lines.

Properties

Applications

Our Abpromise guarantee covers the use of ab175075 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/2000. Predicted molecular weight: 52 kDa.
IHC-P 1/50 - 1/200.

ab171870 - Rabbit polyclonal IgG, is suitable for use as an isotype control with this antibody.

Target

  • Function
    Factor IX is a vitamin K-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor X to its active form in the presence of Ca(2+) ions, phospholipids, and factor VIIIa.
  • Tissue specificity
    Synthesized primarily in the liver and secreted in plasma.
  • Involvement in disease
    Defects in F9 are the cause of recessive X-linked hemophilia B (HEMB) [MIM:306900]; also known as Christmas disease.
    Note=Mutations in position 43 (Oxford-3, San Dimas) and 46 (Cambridge) prevents cleavage of the propeptide, mutation in position 93 (Alabama) probably fails to bind to cell membranes, mutation in position 191 (Chapel-Hill) or in position 226 (Nagoya OR Hilo) prevent cleavage of the activation peptide.
    Defects in F9 are the cause of thrombophilia due to factor IX defect (THR-FIX) [MIM:300807]. A hemostatic disorder characterized by a tendency to thrombosis.
  • Sequence similarities
    Belongs to the peptidase S1 family.
    Contains 2 EGF-like domains.
    Contains 1 Gla (gamma-carboxy-glutamate) domain.
    Contains 1 peptidase S1 domain.
  • Domain
    Calcium binds to the gamma-carboxyglutamic acid (Gla) residues and, with stronger affinity, to another site, beyond the Gla domain.
  • Post-translational
    modifications
    Activated by factor XIa, which excises the activation peptide.
    The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.
  • Cellular localization
    Secreted.
  • Information by UniProt
  • Database links
  • Alternative names
    • Christmas Disease antibody
    • Christmas factor antibody
    • Coagulant factor IX antibody
    • Coagulation factor 9 antibody
    • Coagulation factor IX antibody
    • Coagulation factor IXa heavy chain antibody
    • F9 antibody
    • FA9_HUMAN antibody
    • Factor 9 antibody
    • Factor IX Deficiency antibody
    • FactorIX antibody
    • FIX antibody
    • Haemophilia B antibody
    • HEMB antibody
    • MGC129641 antibody
    • MGC129642 antibody
    • P19 antibody
    • Plasma Thromboplastic Component antibody
    • Plasma thromboplastin component antibody
    • PTC antibody
    see all

Images

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of rat kidney tissue labelling Factor IX with ab175075 at 1/100. Magnification: 200x.
  • Anti-Factor IX antibody (ab175075) at 1/500 dilution + extracts of HO-8910 cell lines

    Predicted band size: 52 kDa

References

ab175075 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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