Overview

  • Product name
    Anti-Factor IX antibody (Biotin)
    See all Factor IX primary antibodies
  • Description
    Rabbit polyclonal to Factor IX (Biotin)
  • Conjugation
    Biotin
  • Tested applications
    Suitable for: WB, RIAmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Human Factor IX purified from human plasma

Properties

Applications

Our Abpromise guarantee covers the use of ab79931 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
RIA
  • Application notes
    RIA: Use at a concentration of 5 µg/ml.
    EIA: Use at a concentration of 5 µg/ml.
    WB: Use at an assay dependent dilution. Predicted molecular weight: 52 kDa.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function
      Factor IX is a vitamin K-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor X to its active form in the presence of Ca(2+) ions, phospholipids, and factor VIIIa.
    • Tissue specificity
      Synthesized primarily in the liver and secreted in plasma.
    • Involvement in disease
      Defects in F9 are the cause of recessive X-linked hemophilia B (HEMB) [MIM:306900]; also known as Christmas disease.
      Note=Mutations in position 43 (Oxford-3, San Dimas) and 46 (Cambridge) prevents cleavage of the propeptide, mutation in position 93 (Alabama) probably fails to bind to cell membranes, mutation in position 191 (Chapel-Hill) or in position 226 (Nagoya OR Hilo) prevent cleavage of the activation peptide.
      Defects in F9 are the cause of thrombophilia due to factor IX defect (THR-FIX) [MIM:300807]. A hemostatic disorder characterized by a tendency to thrombosis.
    • Sequence similarities
      Belongs to the peptidase S1 family.
      Contains 2 EGF-like domains.
      Contains 1 Gla (gamma-carboxy-glutamate) domain.
      Contains 1 peptidase S1 domain.
    • Domain
      Calcium binds to the gamma-carboxyglutamic acid (Gla) residues and, with stronger affinity, to another site, beyond the Gla domain.
    • Post-translational
      modifications
      Activated by factor XIa, which excises the activation peptide.
      The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.
    • Cellular localization
      Secreted.
    • Information by UniProt
    • Database links
    • Alternative names
      • Christmas Disease antibody
      • Christmas factor antibody
      • Coagulant factor IX antibody
      • Coagulation factor 9 antibody
      • Coagulation factor IX antibody
      • Coagulation factor IXa heavy chain antibody
      • F9 antibody
      • FA9_HUMAN antibody
      • Factor 9 antibody
      • Factor IX Deficiency antibody
      • FactorIX antibody
      • FIX antibody
      • Haemophilia B antibody
      • HEMB antibody
      • MGC129641 antibody
      • MGC129642 antibody
      • P19 antibody
      • Plasma Thromboplastic Component antibody
      • Plasma thromboplastin component antibody
      • PTC antibody
      see all

    References

    ab79931 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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