Anti-Factor V antibody (Biotin) (ab48230)

Overview

  • Product name
    Anti-Factor V antibody (Biotin)
    See all Factor V primary antibodies
  • Description
    Rabbit polyclonal to Factor V (Biotin)
  • Conjugation
    Biotin
  • Tested applications
    Suitable for: RIA, IP, WB, ELISAmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Full length native Factor V purified from plasma (Human).

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • Storage buffer
    Preservative: 0.01% Thimerosal (merthiolate)
    Constituents: 50% Glycerol, PBS, pH 7.5
  • Concentration information loading...
  • Purity
    Protein G purified
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab48230 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
RIA Use at an assay dependent dilution.
IP Use at an assay dependent dilution.
WB Use at an assay dependent dilution. Predicted molecular weight: 251 kDa.
ELISA Use at an assay dependent dilution.

Target

  • Function
    Central regulator of hemostasis. It serves as a critical cofactor for the prothrombinase activity of factor Xa that results in the activation of prothrombin to thrombin.
  • Tissue specificity
    Plasma.
  • Involvement in disease
    Factor V deficiency
    Thrombophilia due to activated protein C resistance
    Budd-Chiari syndrome
    Ischemic stroke
    Pregnancy loss, recurrent, 1
  • Sequence similarities
    Belongs to the multicopper oxidase family.
    Contains 3 F5/8 type A domains.
    Contains 2 F5/8 type C domains.
    Contains 6 plastocyanin-like domains.
  • Domain
    Domain B contains 35 x 9 AA tandem repeats, and 2 x 17 AA repeats.
  • Post-translational
    modifications
    Thrombin activates factor V proteolytically to the active cofactor, factor Va (formation of a heavy chain at the N-terminus and a light chain at the C-terminus).
    Sulfation is required for efficient thrombin cleavage and activation and for full procoagulant activity.
    Activated protein C inactivates factor V and factor Va by proteolytic degradation.
    Phosphorylation sites are present in the extracellular medium.
  • Cellular localization
    Secreted.
  • Information by UniProt
  • Database links
  • Alternative names
    • Activated protein C cofactor antibody
    • APC cofactor antibody
    • coagulation factor V (proaccelerin, labile factor) antibody
    • Coagulation factor V antibody
    • coagulation factor V jinjiang A2 domain antibody
    • Coagulation factor V light chain antibody
    • F5 antibody
    • FA5_HUMAN antibody
    • Factor V Leiden antibody
    • FactorV antibody
    • FVL antibody
    • Labile factor antibody
    • PCCF antibody
    • Proaccelerin antibody
    • proaccelerin, labile factor antibody
    • Protein C cofactor antibody
    • RPRGL1 antibody
    • THPH2 antibody
    see all

References

ab48230 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

First of all I would like to apologise for the delay in getting back to you.I really appreciate your patience and comprehension.

-In regards to antibody ab21037, I am afraid it has only been tested against human factor V, therefore it is unkn...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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