Overview

  • Product name
    Anti-Factor V antibody [EPR5191]
    See all Factor V primary antibodies
  • Description
    Rabbit monoclonal [EPR5191] to Factor V
  • Tested applications
    Suitable for: Flow Cyt, WBmore details
    Unsuitable for: ICC,IHC-P or IP
  • Species reactivity
    Reacts with: Human
  • Immunogen

    A synthetic peptide corresponding to residues in the light chain of Human Factor V

  • Positive control
    • Human plasma and platelet lysates
  • General notes

    This product is a recombinant rabbit monoclonal antibody.

    Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents

Properties

Applications

Our Abpromise guarantee covers the use of ab108614 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Flow Cyt Use at an assay dependent concentration. PubMed: 27492853
WB 1/1000 - 1/10000. Predicted molecular weight: 252 kDa.
  • Application notes
    Is unsuitable for ICC,IHC-P or IP.
  • Target

    • Function
      Central regulator of hemostasis. It serves as a critical cofactor for the prothrombinase activity of factor Xa that results in the activation of prothrombin to thrombin.
    • Tissue specificity
      Plasma.
    • Involvement in disease
      Factor V deficiency
      Thrombophilia due to activated protein C resistance
      Budd-Chiari syndrome
      Ischemic stroke
      Pregnancy loss, recurrent, 1
    • Sequence similarities
      Belongs to the multicopper oxidase family.
      Contains 3 F5/8 type A domains.
      Contains 2 F5/8 type C domains.
      Contains 6 plastocyanin-like domains.
    • Domain
      Domain B contains 35 x 9 AA tandem repeats, and 2 x 17 AA repeats.
    • Post-translational
      modifications
      Thrombin activates factor V proteolytically to the active cofactor, factor Va (formation of a heavy chain at the N-terminus and a light chain at the C-terminus).
      Sulfation is required for efficient thrombin cleavage and activation and for full procoagulant activity.
      Activated protein C inactivates factor V and factor Va by proteolytic degradation.
      Phosphorylation sites are present in the extracellular medium.
    • Cellular localization
      Secreted.
    • Information by UniProt
    • Database links
    • Alternative names
      • Activated protein C cofactor antibody
      • APC cofactor antibody
      • coagulation factor V (proaccelerin, labile factor) antibody
      • Coagulation factor V antibody
      • coagulation factor V jinjiang A2 domain antibody
      • Coagulation factor V light chain antibody
      • F5 antibody
      • FA5_HUMAN antibody
      • Factor V Leiden antibody
      • FactorV antibody
      • FVL antibody
      • Labile factor antibody
      • PCCF antibody
      • Proaccelerin antibody
      • proaccelerin, labile factor antibody
      • Protein C cofactor antibody
      • RPRGL1 antibody
      • THPH2 antibody
      see all

    Images

    • All lanes : Anti-Factor V antibody [EPR5191] (ab108614) at 1/1000 dilution

      Lane 1 : Human plasma lysate
      Lane 2 : Human platelet lysate

      Lysates/proteins at 10 µg per lane.


      Predicted band size : 252 kDa

    References

    This product has been referenced in:
    • Kaliberov SA  et al. Retargeted adenoviruses for radiation-guided gene delivery. Cancer Gene Ther N/A:N/A (2016). Flow Cyt ; Human . Read more (PubMed: 27492853) »

    See 1 Publication for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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