Overview

  • Product nameAnti-Factor V antibody [EPR5191]
    See all Factor V primary antibodies
  • Description
    Rabbit monoclonal [EPR5191] to Factor V
  • Tested applicationsSuitable for: Flow Cyt, WBmore details
    Unsuitable for: ICC,IHC-P or IP
  • Species reactivity
    Reacts with: Human
  • Immunogen

    A synthetic peptide corresponding to residues in the light chain of Human Factor V

  • Positive control
    • Human plasma and platelet lysates
  • General notes

    This product is a recombinant rabbit monoclonal antibody.

    Produced using Abcam’s RabMAb® technology. RabMAb® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.

    Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.

Properties

Applications

Our Abpromise guarantee covers the use of ab108614 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Flow Cyt Use at an assay dependent concentration. PubMed: 27492853
WB 1/1000 - 1/10000. Predicted molecular weight: 252 kDa.
  • Application notesIs unsuitable for ICC,IHC-P or IP.
  • Target

    • FunctionCentral regulator of hemostasis. It serves as a critical cofactor for the prothrombinase activity of factor Xa that results in the activation of prothrombin to thrombin.
    • Tissue specificityPlasma.
    • Involvement in diseaseFactor V deficiency
      Thrombophilia due to activated protein C resistance
      Budd-Chiari syndrome
      Ischemic stroke
      Pregnancy loss, recurrent, 1
    • Sequence similaritiesBelongs to the multicopper oxidase family.
      Contains 3 F5/8 type A domains.
      Contains 2 F5/8 type C domains.
      Contains 6 plastocyanin-like domains.
    • DomainDomain B contains 35 x 9 AA tandem repeats, and 2 x 17 AA repeats.
    • Post-translational
      modifications
      Thrombin activates factor V proteolytically to the active cofactor, factor Va (formation of a heavy chain at the N-terminus and a light chain at the C-terminus).
      Sulfation is required for efficient thrombin cleavage and activation and for full procoagulant activity.
      Activated protein C inactivates factor V and factor Va by proteolytic degradation.
      Phosphorylation sites are present in the extracellular medium.
    • Cellular localizationSecreted.
    • Information by UniProt
    • Database links
    • Alternative names
      • Activated protein C cofactor antibody
      • APC cofactor antibody
      • coagulation factor V (proaccelerin, labile factor) antibody
      • Coagulation factor V antibody
      • coagulation factor V jinjiang A2 domain antibody
      • Coagulation factor V light chain antibody
      • F5 antibody
      • FA5_HUMAN antibody
      • Factor V Leiden antibody
      • FactorV antibody
      • FVL antibody
      • Labile factor antibody
      • PCCF antibody
      • Proaccelerin antibody
      • proaccelerin, labile factor antibody
      • Protein C cofactor antibody
      • RPRGL1 antibody
      • THPH2 antibody
      see all

    Anti-Factor V antibody [EPR5191] images

    • All lanes : Anti-Factor V antibody [EPR5191] (ab108614) at 1/1000 dilution

      Lane 1 : Human plasma lysate
      Lane 2 : Human platelet lysate

      Lysates/proteins at 10 µg per lane.


      Predicted band size : 252 kDa

    References for Anti-Factor V antibody [EPR5191] (ab108614)

    This product has been referenced in:
    • Kaliberov SA  et al. Retargeted adenoviruses for radiation-guided gene delivery. Cancer Gene Ther N/A:N/A (2016). Flow Cyt ; Human . Read more (PubMed: 27492853) »

    See 1 Publication for this product

    Product Wall

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"