Anti-Factor V Light Chain antibody (ab61413)

Overview

  • Product nameAnti-Factor V Light Chain antibody
    See all Factor V Light Chain primary antibodies
  • Description
    Mouse monoclonal to Factor V Light Chain
  • SpecificityRecognises human factor V and Va, light chain (fragment E, 74,000) of factor Va
  • Tested applicationsSuitable for: WB, ELISA, RIAmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Full length native purified Human Factor V Light Chain

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage bufferPreservative: None
    Constituents: 50% Glycerol, Water
  • Concentration information loading...
  • PurityIon Exchange Chromatography
  • Purification notesSalt fractionation followed by gel filtration and ion exchange chromatography
  • ClonalityMonoclonal
  • IsotypeIgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab61413 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use at an assay dependent concentration. Predicted molecular weight: 252 kDa.
ELISA Use at an assay dependent dilution.
RIA Use at an assay dependent dilution.

Target

  • RelevanceCoagulation factor V is a cofactor that participates with factor Xa to activate prothrombin to thrombin. Factor Va is composed of a heavy chain and a light chain, noncovalently bound. The interaction between the two chains is calcium-dependent. Thrombin activates factor V proteolytically to the active cofactor, factor Va (formation of a heavy chain at the N-terminus and a light chain at the C-terminus). Sulfation is required for efficient thrombin cleavage and activation and for full procoagulant activity. Defects in F5 are the cause of Owren parahemophilia which is an hemorrhagic diastesis. Defects in F5 are the cause of resistance to activated protein C (APCR). APCR is a form of thrombophilia. The APCR mutation is found in about 5% of the population which suggest that a slight thrombotic tendency may confer some advantage in fetal implantation.
  • Cellular localizationSecreted
  • Database links
  • Alternative names
    • Activated protein C cofactor antibody
    • Coagulation factor V antibody
    • Coagulation factor V heavy chain antibody
    • Coagulation factor V light chain antibody
    • F5 antibody
    see all

References for Anti-Factor V Light Chain antibody (ab61413)

ab61413 has not yet been referenced specifically in any publications.

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The clone number for ab61348 is AHV-5146 and for ab61413 it is AHV-5108.

I will send you the clone nunmber for ab1015 soon.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"