Overview

  • Product nameAnti-Factor VII antibody
    See all Factor VII primary antibodies
  • Description
    Sheep polyclonal to Factor VII
  • Specificityab104564 is specific for Factor VII as determined by immunodiffusion. Identity was established with purified Factor VII.
  • Tested applicationsSuitable for: IP, ELISA, IHC-P, Neutralisingmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Human Factor VII purified from plasma.

  • Positive control
    • Human Liver tissue

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage bufferPreservative: None
    Constituents: 50% Glycerol, HEPES, pH 7.4
  • Concentration information loading...
  • PurityAmmonium Sulphate Precipitation
  • ClonalityPolyclonal
  • IsotypeIgG
  • Research areas

Associated products

Applications

Our Abpromise guarantee covers the use of ab104564 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IP Use at an assay dependent dilution.
ELISA Use at an assay dependent dilution.
IHC-P Use a concentration of 5 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
Neutralising Use at an assay dependent dilution.

Target

  • FunctionInitiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a zymogen form. Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minor proteolysis. In the presence of tissue factor and calcium ions, factor VIIa then converts factor X to factor Xa by limited proteolysis. Factor VIIa will also convert factor IX to factor IXa in the presence of tissue factor and calcium.
  • Tissue specificityPlasma.
  • Involvement in diseaseDefects in F7 are the cause of factor VII deficiency (FA7D) [MIM:227500]. FA7D is a rare hereditary hemorrhagic disease. The clinical picture can be very severe, with the early occurrence of intracerebral hemorrhages or hemarthroses, or, in contrast, moderate with cutaneous-mucosal hemorrhages (epistaxis, menorrhagia) or hemorrhages provoked by a surgical intervention. Numerous subjects are completely asymptomatic despite a very low F7 level.
  • Sequence similaritiesBelongs to the peptidase S1 family.
    Contains 2 EGF-like domains.
    Contains 1 Gla (gamma-carboxy-glutamate) domain.
    Contains 1 peptidase S1 domain.
  • Post-translational
    modifications
    The vitamin K-dependent, enzymatic carboxylation of some glutamate residues allows the modified protein to bind calcium.
    The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.
  • Cellular localizationSecreted.
  • Information by UniProt
  • Database links
  • Alternative names
    • coagulation factor VII (serum prothrombin conversion accelerator) antibody
    • Coagulation factor VII antibody
    • Eptacog alfa antibody
    • F7 antibody
    • FA7_HUMAN antibody
    • Factor VII antibody
    • Factor VII heavy chain antibody
    • Factor VII light chain antibody
    • FVII coagulation protein antibody
    • OTTHUMP00000018733 antibody
    • OTTHUMP00000018734 antibody
    • Proconvertin antibody
    • Serum prothrombin conversion accelerator antibody
    • SPCA antibody
    see all

Anti-Factor VII antibody images

  • ab104564, at 5 ug/ml, staining Factor VII in formalin-fixed, paraffin-embedded Human Liver by Immunohistochemistry, using a biotinylated secondary antibody, alkaline phosphatase-streptavidin and chromogen.

References for Anti-Factor VII antibody (ab104564)

ab104564 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab104564.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"