Anti-Factor VIII + VIII A2domain antibody [012] (ab21210)

Overview

  • Product name
    Anti-Factor VIII + VIII A2domain antibody [012]
    See all Factor VIII + VIII A2domain primary antibodies
  • Description
    Mouse monoclonal [012] to Factor VIII + VIII A2domain
  • Specificity
    ab21210 binds both human factor VIII and human factor VIIIa in solid-phase ELISA and human factor VIII A2 domain in immunoblotting techniques.
  • Tested applications
    Suitable for: ELISA, WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Full length native protein (purified) corresponding to Human Factor VIII + VIII A2domain.

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
  • Storage buffer
    Preservative: 0.01% Sodium Azide
    Constituents: 0.15M Sodium chloride, 10mM Sodium phosphate. pH 7.4
  • Concentration information loading...
  • Purity
    IgG fraction
  • Purification notes
    Gel filtration and ion exchange chromatography (SDS-PAGE).
  • Clonality
    Monoclonal
  • Clone number
    012
  • Myeloma
    NS1
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab21210 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA Use at an assay dependent dilution.
WB Use at an assay dependent dilution. Predicted molecular weight: 27 kDa. Dilution optimised using Chromogenic detection.

Target

  • Relevance
    Haemophilia A is an X-linked, recessive, bleeding disorder caused by a deficiency in the activity of coagulation factor VIII. Affected individuals develop a variable phenotype of haemorrhage into joints and muscles, easy bruising, and prolonged bleeding from wounds. The disorder is caused by heterogeneous mutations in the factor VIII gene. Up to 30% of haemophilia A patients given therapeutic fVIII can make inhibitory antibodies, the majority of which are reactive with its C2 and A2 domains.
  • Cellular localization
    Secreted
  • Database links
  • Alternative names
    • AHF antibody
    • Antihemophilic factor antibody
    • Coagulation factor VIII antibody
    • F8 antibody
    • F8B antibody
    • F8C antibody
    • Factor VIII antibody
    • FVIII antibody
    • HEMA antibody
    see all

References for Anti-Factor VIII + VIII A2domain antibody [012] (ab21210)

ab21210 has not yet been referenced specifically in any publications.

Product Wall

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Thank you for your enquiry. I have enquired at the source of the product but unfortunately, it seems that we do not have any available information on the epitope sequence for both these antibodies. I am sorry I can't be of more assistance in thi...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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