Anti-Factor VIII + VIII A2domain antibody (ab168752)

Overview

  • Product name
    Anti-Factor VIII + VIII A2domain antibody
  • Description
    Rabbit polyclonal to Factor VIII + VIII A2domain
  • Host species
    Rabbit
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Dog
  • Immunogen

    Full length protein corresponding to amino acids 1-216 of Human Factor VIII + VIII A2domain Isoform 2 (NP_063916.1)

  • Positive control
    • Factor VIII + VIII A2domain transfected 293T cell lysate.

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term.
  • Storage buffer
    pH: 7.20
    Constituent: 99% PBS
  • Concentration information loading...
  • Purity
    Protein A purified
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab168752 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 27 kDa.

Target

  • Relevance
    Haemophilia A is an X-linked, recessive, bleeding disorder caused by a deficiency in the activity of coagulation factor VIII. Affected individuals develop a variable phenotype of haemorrhage into joints and muscles, easy bruising, and prolonged bleeding from wounds. The disorder is caused by heterogeneous mutations in the factor VIII gene. Up to 30% of haemophilia A patients given therapeutic fVIII can make inhibitory antibodies, the majority of which are reactive with its C2 and A2 domains.
  • Cellular localization
    Secreted
  • Database links
  • Alternative names
    • AHF antibody
    • Antihemophilic factor antibody
    • Coagulation factor VIII antibody
    • F8 antibody
    • F8B antibody
    • F8C antibody
    • Factor VIII antibody
    • FVIII antibody
    • HEMA antibody
    see all

Images

  • All lanes : Anti-Factor VIII + VIII A2domain antibody (ab168752) at 1 µg/ml

    Lane 1 : Factor VIII + VIII A2domain transfected 293T cell lysate (24.60 KDa)
    Lane 2 : Non-transfected 293T cell lysate

    Lysates/proteins at 15 µl per lane.

    Secondary
    All lanes : Goat Anti-Rabbit IgG (H+L), Peroxidase Conjugated secondary antibody at 1/7500 dilution

    Predicted band size: 27 kDa

References

ab168752 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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