Overview

  • Product name
  • Description
    Sheep polyclonal to Factor X
  • Tested applications
    Suitable for: ELISA, IHC-P, Immunodiffusion, Immunoelectrophoresismore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Macaque monkey
  • Immunogen

    Full length native Human Factor X, purified from human plasma, activated and the active site blocked.

  • Positive control
    • Human small intestine vessels, Human liver vessels.

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage buffer
    pH: 7.40
    Constituents: 0.238% HEPES, 0.8766% Sodium chloride, 50% Glycerol
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab110138 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA Use at an assay dependent dilution.
IHC-P Use a concentration of 5 µg/ml.
Immunodiffusion Use at an assay dependent dilution.
Immunoelectrophoresis Use at an assay dependent dilution.

Target

  • Function
    Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting.
  • Tissue specificity
    Plasma; synthesized in the liver.
  • Involvement in disease
    Defects in F10 are the cause of factor X deficiency (FA10D) [MIM:227600]. A hemorrhagic disease with variable presentation. Affected individuals can manifest prolonged nasal and mucosal hemorrhage, menorrhagia, hematuria, and occasionally hemarthrosis. Some patients do not have clinical bleeding diathesis.
  • Sequence similarities
    Belongs to the peptidase S1 family.
    Contains 2 EGF-like domains.
    Contains 1 Gla (gamma-carboxy-glutamate) domain.
    Contains 1 peptidase S1 domain.
  • Post-translational
    modifications
    The vitamin K-dependent, enzymatic carboxylation of some glutamate residues allows the modified protein to bind calcium.
    N- and O-glycosylated.
    The activation peptide is cleaved by factor IXa (in the intrinsic pathway), or by factor VIIa (in the extrinsic pathway).
    The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.
  • Cellular localization
    Secreted.
  • Information by UniProt
  • Database links
  • Form
    Cleaved into the following 3 chains: 1. Factor X light chain 2. Factor X heavy chain 3. Activated factor Xa heavy chain
  • Alternative names
    • Activated factor Xa heavy chain antibody
    • Coagulation factor X antibody
    • F10 antibody
    • FA10_HUMAN antibody
    • factor Xa antibody
    • FX antibody
    • FXA antibody
    • Prothrombinase antibody
    • Stuart factor antibody
    • Stuart Prower factor antibody
    • Stuart-Prower factor antibody
    see all

Anti-Factor X antibody images

  • ab110138, at 5 µg/ml, staining F10 in vessels in Human small intestine by immunohistochemistry.
  • ab110138, at 5 µg/ml, staining a vessel in Human liver by immunohistochemistry.

References for Anti-Factor X antibody (ab110138)

ab110138 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab110138.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

Sign up