Anti-Factor XI antibody (Biotin) (ab105847)

Overview

  • Product nameAnti-Factor XI antibody (Biotin)
    See all Factor XI primary antibodies
  • Description
    Rabbit polyclonal to Factor XI (Biotin)
  • ConjugationBiotin
  • Tested applicationsSuitable for: WB, ELISA, RIAmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Human Factor XI purified from Human plasma.

Properties

Applications

Our Abpromise guarantee covers the use of ab105847 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use at an assay dependent dilution. Predicted molecular weight: 70 kDa.
ELISA Use at an assay dependent dilution.
RIA Use at an assay dependent dilution.

Target

  • FunctionFactor XI triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX.
  • Tissue specificityIsoform 2 is produced by platelets and megakaryocytes but absent from other blood cells.
  • Involvement in diseaseDefects in F11 are the cause of factor XI deficiency (FA11D) [MIM:612416]; also known as plasma thromboplastin antecedent deficiency or Rosenthal syndrome. It is a hemorrhagic disease characterized by reduced levels and activity of factor XI resulting in moderate bleeding symptoms, usually occurring after trauma or surgery. Patients usually do not present spontaneous bleeding but women can present with menorrhagia. Hemorrhages are usually moderate.
  • Sequence similaritiesBelongs to the peptidase S1 family. Plasma kallikrein subfamily.
    Contains 4 apple domains.
    Contains 1 peptidase S1 domain.
  • Post-translational
    modifications
    Activated by factor XIIa (or XII), which cleaves each polypeptide after Arg-387 into the light chain, which contains the active site, and the heavy chain, which associates with high molecular weight (HMW) kininogen.
  • Cellular localizationSecreted.
  • Information by UniProt
  • Database links
  • Alternative names
    • Coagulation factor XI antibody
    • Coagulation factor XIa light chain antibody
    • F11 antibody
    • FA11_HUMAN antibody
    • FXI antibody
    • MGC141891 antibody
    • Plasma thromboplastin antecedent antibody
    • PTA antibody
    see all

References for Anti-Factor XI antibody (Biotin) (ab105847)

ab105847 has not yet been referenced specifically in any publications.

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