Anti-FXI antibody [MM0193-7C38] (ab89335)
Key features and details
- Mouse monoclonal [MM0193-7C38] to FXI
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG2
Overview
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Product name
Anti-FXI antibody [MM0193-7C38]
See all FXI primary antibodies -
Description
Mouse monoclonal [MM0193-7C38] to FXI -
Host species
Mouse -
Tested applications
Suitable for: WBmore details -
Species reactivity
Reacts with: Human -
Immunogen
Recombinant full length protein corresponding to Human FXI.
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Positive control
- WB: Human placenta tissue lysate.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
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Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
Storage buffer
Constituent: PBS -
Concentration information loading...
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Purity
Protein G purified -
Purification notes
The IgG fraction of culture supernatant was purified by Protein G affinity chromatography and lyophilized from a 0.2 µm filtered solution. -
Clonality
Monoclonal -
Clone number
MM0193-7C38 -
Isotype
IgG2 -
Research areas
Associated products
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Compatible Secondaries
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab89335 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB |
1/500 - 1/1000. Predicted molecular weight: 70 kDa.
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Notes |
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WB
1/500 - 1/1000. Predicted molecular weight: 70 kDa. |
Target
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Function
Factor XI triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX. -
Tissue specificity
Isoform 2 is produced by platelets and megakaryocytes but absent from other blood cells. -
Involvement in disease
Defects in F11 are the cause of factor XI deficiency (FA11D) [MIM:612416]; also known as plasma thromboplastin antecedent deficiency or Rosenthal syndrome. It is a hemorrhagic disease characterized by reduced levels and activity of factor XI resulting in moderate bleeding symptoms, usually occurring after trauma or surgery. Patients usually do not present spontaneous bleeding but women can present with menorrhagia. Hemorrhages are usually moderate. -
Sequence similarities
Belongs to the peptidase S1 family. Plasma kallikrein subfamily.
Contains 4 apple domains.
Contains 1 peptidase S1 domain. -
Post-translational
modificationsActivated by factor XIIa (or XII), which cleaves each polypeptide after Arg-387 into the light chain, which contains the active site, and the heavy chain, which associates with high molecular weight (HMW) kininogen. -
Cellular localization
Secreted. - Information by UniProt
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Database links
- Entrez Gene: 2160 Human
- Omim: 264900 Human
- SwissProt: P03951 Human
- Unigene: 1430 Human
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Alternative names
- Coagulation factor XI antibody
- Coagulation factor XIa light chain antibody
- F11 antibody
see all
Images
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Anti-FXI antibody [MM0193-7C38] (ab89335) at 1/500 dilution + Human placenta tissue lysate
Predicted band size: 70 kDa
Observed band size: 69 kDa why is the actual band size different from the predicted?
Datasheets and documents
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Datasheet download
References (0)
ab89335 has not yet been referenced specifically in any publications.