Anti-Factor XI antibody [MM0193-7C38] (ab89335)

Overview

  • Product name
    Anti-Factor XI antibody [MM0193-7C38]
    See all Factor XI primary antibodies
  • Description
    Mouse monoclonal [MM0193-7C38] to Factor XI
  • Specificity
    ab89335 detects Factor XI.
  • Tested applications
    Suitable for: WB, Neutralisingmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant full length Human Factor XI protein.

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage buffer
    Preservative: None
    Constituents: PBS
  • Concentration information loading...
  • Purity
    Protein G purified
  • Purification notes
    The IgG fraction of culture supernatant was purified by Protein G affinity chromatography and lyophilized from a 0.2 µm filtered solution.
  • Clonality
    Monoclonal
  • Clone number
    MM0193-7C38
  • Isotype
    IgG2
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab89335 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Predicted molecular weight: 69 kDa.
Neutralising Use at an assay dependent dilution.

Target

  • Function
    Factor XI triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX.
  • Tissue specificity
    Isoform 2 is produced by platelets and megakaryocytes but absent from other blood cells.
  • Involvement in disease
    Defects in F11 are the cause of factor XI deficiency (FA11D) [MIM:612416]; also known as plasma thromboplastin antecedent deficiency or Rosenthal syndrome. It is a hemorrhagic disease characterized by reduced levels and activity of factor XI resulting in moderate bleeding symptoms, usually occurring after trauma or surgery. Patients usually do not present spontaneous bleeding but women can present with menorrhagia. Hemorrhages are usually moderate.
  • Sequence similarities
    Belongs to the peptidase S1 family. Plasma kallikrein subfamily.
    Contains 4 apple domains.
    Contains 1 peptidase S1 domain.
  • Post-translational
    modifications
    Activated by factor XIIa (or XII), which cleaves each polypeptide after Arg-387 into the light chain, which contains the active site, and the heavy chain, which associates with high molecular weight (HMW) kininogen.
  • Cellular localization
    Secreted.
  • Information by UniProt
  • Database links
  • Alternative names
    • Coagulation factor XI antibody
    • Coagulation factor XIa light chain antibody
    • F11 antibody
    • FA11_HUMAN antibody
    • FXI antibody
    • MGC141891 antibody
    • Plasma thromboplastin antecedent antibody
    • PTA antibody
    see all

References for Anti-Factor XI antibody [MM0193-7C38] (ab89335)

ab89335 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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