Overview

  • Product nameAnti-Factor XIa antibody
    See all Factor XIa primary antibodies
  • Description
    Rabbit polyclonal to Factor XIa
  • Tested applicationsSuitable for: WB, RIA, ELISAmore details
  • Species reactivity
    Reacts with: Cow
  • Immunogen

    Full length native protein Bovine FXIa purified from bovine plasma

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage bufferPreservative: 0.01% Thimerosal (merthiolate)
    Constituents: 50% Glycerol, PBS, pH 7.5
  • Concentration information loading...
  • PurityProtein G purified
  • ClonalityPolyclonal
  • IsotypeIgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab100878 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use at an assay dependent concentration. Predicted molecular weight: 70 kDa.
RIA Use at an assay dependent concentration.
ELISA Use at an assay dependent concentration.

Target

  • FunctionFactor XI triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX.
  • Tissue specificityIsoform 2 is produced by platelets and megakaryocytes but absent from other blood cells.
  • Involvement in diseaseDefects in F11 are the cause of factor XI deficiency (FA11D) [MIM:612416]; also known as plasma thromboplastin antecedent deficiency or Rosenthal syndrome. It is a hemorrhagic disease characterized by reduced levels and activity of factor XI resulting in moderate bleeding symptoms, usually occurring after trauma or surgery. Patients usually do not present spontaneous bleeding but women can present with menorrhagia. Hemorrhages are usually moderate.
  • Sequence similaritiesBelongs to the peptidase S1 family. Plasma kallikrein subfamily.
    Contains 4 apple domains.
    Contains 1 peptidase S1 domain.
  • Post-translational
    modifications
    Activated by factor XIIa (or XII), which cleaves each polypeptide after Arg-387 into the light chain, which contains the active site, and the heavy chain, which associates with high molecular weight (HMW) kininogen.
  • Cellular localizationSecreted.
  • Information by UniProt
  • Database links
  • Alternative names
    • coagulation factor XI antibody
    • Coagulation factor XIa light chain antibody
    • F11 antibody
    • FA11_HUMAN antibody
    • FXI antibody
    • MGC141891 antibody
    • Plasma thromboplastin antecedent antibody
    • Platelet coagulation factor XI antibody
    • PTA antibody
    see all

References for Anti-Factor XIa antibody (ab100878)

ab100878 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"