Anti-Factor XII light chain antibody [C6B7] (ab1008)

Overview

  • Product nameAnti-Factor XII light chain antibody [C6B7]
  • Description
    Mouse monoclonal [C6B7] to Factor XII light chain
  • SpecificityThis antibody reacts with the light chain of human Factor XII.
  • Tested applicationsSuitable for: ELISA, Neutralisingmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Purified human Factor XII.

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage bufferConstituents: PBS, pH 7.2
  • Concentration information loading...
  • PurityProtein G purified
  • ClonalityMonoclonal
  • Clone numberC6B7
  • IsotypeIgG1
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab1008 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA
Neutralising
  • Application notesDilute in PBS or medium which is identical to that used in the assay system.
    At 100 nM, this antibody inhibits 50% of Factor XII activity.
    This antibody can also be used in a coagulation assay
  • Target

    • RelevanceCoagulation factor XII circulates in blood as a zymogen. This single chain zymogen is converted to a two chain serine protease with an heavy chain (alpha factor XIIa) and a light chain. Factor XII, prekallikrein, and HMW kininogen form a complex bound to an anionic surface. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then to beta-factor XIIa. Alpha-factor XIIa activates factor XI to factor XIa.
    • Cellular localizationSecreted
    • Database links
    • Alternative names
      • Coagulation factor XII antibody
      • Coagulation factor XIIa light chain antibody
      • F12 antibody
      • Hageman factor antibody

    References for Anti-Factor XII light chain antibody [C6B7] (ab1008)

    ab1008 has not yet been referenced specifically in any publications.

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    Thank you very much for your interest in ab1008. To our knowledge, ab1008 has not been tested in western blot. Therefore, I can offer a discount off a future purchase if you buy ab1008 now, test it in western blot and submit feedback to us in the form ...

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"