Overview

  • Product nameAnti-Factor XIIIa antibody
    See all Factor XIIIa primary antibodies
  • Description
    Mouse polyclonal to Factor XIIIa
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Full length Human Factor XIIIa (AAH27963.1)

  • Positive control
    • Human pancreas tissue lysate, Factor XIIIa transfected 293T cell lysate.

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab88905 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Predicted molecular weight: 83 kDa.

Target

  • FunctionFactor XIII is activated by thrombin and calcium ion to a transglutaminase that catalyzes the formation of gamma-glutamyl-epsilon-lysine cross-links between fibrin chains, thus stabilizing the fibrin clot. Also cross-link alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin.
  • Involvement in diseaseDefects in F13A1 are the cause of factor XIII subunit A deficiency (FA13AD) [MIM:613225]. FA13AD is an autosomal recessive disorder characterized by a life-long bleeding tendency, impaired wound healing and spontaneous abortion in affected women.
  • Sequence similaritiesBelongs to the transglutaminase superfamily. Transglutaminase family.
  • Post-translational
    modifications
    The activation peptide is released by thrombin.
  • Cellular localizationCytoplasm. Secreted. Secreted into the blood plasma. Cytoplasmic in most tissues, but also secreted in the blood plasma.
  • Information by UniProt
  • Database links
  • Alternative names
    • bA525O21.1 (coagulation factor XIII, A1 polypeptide) antibody
    • Coagulation factor XIII A chain antibody
    • Coagulation factor XIII A1 polypeptide antibody
    • Coagulation factor XIII A1 subunit antibody
    • Coagulation factor XIII, A polypeptide antibody
    • Coagulation factor XIIIa antibody
    • F13A antibody
    • F13A_HUMAN antibody
    • F13a1 antibody
    • Factor XIIIA antibody
    • Fibrin stabilizing factor, A subunit antibody
    • Fibrinoligase antibody
    • FSF, A subunit antibody
    • Protein glutamine gamma glutamyltransferase A chain antibody
    • Protein-glutamine gamma-glutamyltransferase A chain antibody
    • TGase antibody
    • Transglutaminase A chain antibody
    • Transglutaminase. plasma antibody
    see all

Anti-Factor XIIIa antibody images

  • Anti-Factor XIIIa antibody (ab88905) at 1/500 dilution + Human pancreas tissue lysate at 50 µg

    Predicted band size : 83 kDa
    Observed band size : 83 kDa
  • All lanes : Anti-Factor XIIIa antibody (ab88905) at 1/500 dilution

    Lane 1 : Factor XIIIa transfected 293T cell lysate
    Lane 2 : Non-transfected lysate

    Lysates/proteins at 25 µg per lane.


    Predicted band size : 83 kDa
    Observed band size : 90 kDa (why is the actual band size different from the predicted?)

References for Anti-Factor XIIIa antibody (ab88905)

ab88905 has not yet been referenced specifically in any publications.

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