Anti-Factor XIIIa antibody [EP3371] (ab79759)

Overview

  • Product nameAnti-Factor XIIIa antibody [EP3371]
    See all Factor XIIIa primary antibodies
  • Description
    Rabbit monoclonal [EP3371] to Factor XIIIa
  • Tested applicationsSuitable for: WB, IPmore details
    Unsuitable for: IHC-P
  • Species reactivity
    Reacts with: Rat, Human
  • Immunogen

    Synthetic peptide, corresponding to N terminal amino acids 75-150 of Human Factor XIIIa

  • Positive control
    • Human placenta, PMBC and rat platelet lysates
  • General notes

    Produced using Abcam’s RabMAb® technology. RabMAb® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.

    Mouse: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.

Properties

Applications

Our Abpromise guarantee covers the use of ab79759 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/2000. Detects a band of approximately 83 kDa (predicted molecular weight: 83 kDa).
IP 1/20.
  • Application notesIs unsuitable for IHC-P.
  • Target

    • FunctionFactor XIII is activated by thrombin and calcium ion to a transglutaminase that catalyzes the formation of gamma-glutamyl-epsilon-lysine cross-links between fibrin chains, thus stabilizing the fibrin clot. Also cross-link alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin.
    • Involvement in diseaseDefects in F13A1 are the cause of factor XIII subunit A deficiency (FA13AD) [MIM:613225]. FA13AD is an autosomal recessive disorder characterized by a life-long bleeding tendency, impaired wound healing and spontaneous abortion in affected women.
    • Sequence similaritiesBelongs to the transglutaminase superfamily. Transglutaminase family.
    • Post-translational
      modifications
      The activation peptide is released by thrombin.
    • Cellular localizationCytoplasm. Secreted. Secreted into the blood plasma. Cytoplasmic in most tissues, but also secreted in the blood plasma.
    • Information by UniProt
    • Database links
    • Alternative names
      • bA525O21.1 (coagulation factor XIII, A1 polypeptide) antibody
      • Coagulation factor XIII A chain antibody
      • Coagulation factor XIII A1 polypeptide antibody
      • Coagulation factor XIII A1 subunit antibody
      • Coagulation factor XIII, A polypeptide antibody
      • Coagulation factor XIIIa antibody
      • F13A antibody
      • F13A_HUMAN antibody
      • F13a1 antibody
      • Factor XIIIA antibody
      • Fibrin stabilizing factor, A subunit antibody
      • Fibrinoligase antibody
      • FSF, A subunit antibody
      • Protein glutamine gamma glutamyltransferase A chain antibody
      • Protein-glutamine gamma-glutamyltransferase A chain antibody
      • TGase antibody
      • Transglutaminase A chain antibody
      • Transglutaminase. plasma antibody
      see all

    Anti-Factor XIIIa antibody [EP3371] images

    • All lanes : Anti-Factor XIIIa antibody [EP3371] (ab79759) at 1/2000 dilution

      Lane 1 : Human placenta lysate
      Lane 2 : PMBC lysate
      Lane 3 : Rat platelets lysate

      Lysates/proteins at 10 µg per lane.

      Secondary
      HRP labelled goat anti-rabbit at 1/2000 dilution

      Predicted band size : 83 kDa
      Observed band size : 83 kDa
      Additional bands at : 65 kDa,75 kDa. We are unsure as to the identity of these extra bands.

    References for Anti-Factor XIIIa antibody [EP3371] (ab79759)

    ab79759 has not yet been referenced specifically in any publications.

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