Anti-FADD antibody [EPR5030] (ab124812)

Overview

• Product nameAnti-FADD antibody [EPR5030]
  See all FADD primary antibodies
• Description
  Rabbit monoclonal [EPR5030] to FADD
• Tested applicationsSuitable for: WB, IHC-P, Flow Cyt, IHC-Frmore details
  Unsuitable for: ICC or IP
• Species reactivity
  Reacts with: Mouse
  
• Immunogen

  Synthetic peptide corresponding to residues in the C-terminus of Mouse FADD.

• Positive control
  • Mouse kidney tissue; Mouse spleen lysate, Raw264.7 cell lysate and NIH/3T3 cell lysate.
• General notes

   

  Human, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.

  Produced using Abcam's RabMAb^® technology. RabMAb^® technology is covered by the following U.S. Patents, No. 5, 675, 063 and/or 7, 429, 487.

  This product is a recombinant rabbit monoclonal antibody.

Properties

• FormLiquid
• Storage instructionsShipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.
• Storage bufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
• PurityTissue culture supernatant
• ClonalityMonoclonal
• Clone numberEPR5030
• IsotypeIgG
• Research areas
  • Cell Biology
  • Apoptosis
  • Intracellular
  • Associated Proteins

  • Cancer
  • Invasion/microenvironment
  • Apoptosis
  • Death receptors & ligands
  • FADD

  • Cancer
  • Cell Death
  • Apoptosis
  • Receptors
  • Death receptors & ligands
  • FADD

  • Cancer
  • Cell Death
  • Necroptosis

Associated products

• Alternative Products
  • Anti-FADD antibody [EPR5030] (Phycoerythrin) (ab211700)
• Compatible Secondaries
  • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
  • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
• Positive Controls
  • Kidney (mouse) normal tissue slides (ab4606)
  • NIH 3T3 whole cell lysate (ab7179)
  • RAW 264.7 whole cell lysate (ab7187)
  • Mouse spleen tissue lysate - total protein (ab7937)

Applications

Target

• FunctionApoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis.
• Tissue specificityExpressed in a wide variety of tissues, except for peripheral blood mononuclear leukocytes.
• Sequence similaritiesContains 1 death domain.
  Contains 1 DED (death effector) domain.
• DomainContains a death domain involved in the binding of the corresponding domain within Fas receptor.

• Target information above from: UniProt accession Q13158 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• Database links
  • Entrez Gene: 14082 Mouse
  • SwissProt: Q61160 Mouse
  • Unigene: 5126 Mouse
• Alternative names
  • FADD antibody
  • FADD protein antibody
  • FADD_HUMAN antibody

  • Fas (TNFRSF6) associated via death domain antibody
  • Fas associated via death domain antibody
  • Fas associating death domain containing protein antibody
  • Fas associating protein antibody
  • Fas associating protein with death domain antibody
  • Fas TNFRSF6 associated via death domain antibody
  • FAS-associated death domain protein antibody
  • FAS-associating death domain-containing protein antibody
  • GIG 3 antibody
  • GIG3 antibody
  • Growth inhibiting gene 3 protein antibody
  • Growth-inhibiting gene 3 protein antibody
  • H sapiens mRNA for mediator of receptor induced toxicity antibody
  • Mediator of receptor induced toxicity antibody
  • MGC8528 antibody
  • MORT 1 antibody
  • MORT1 antibody
  • Protein FADD antibody

  see all