Overview

Description

  • Nature
    Synthetic

Associated products

Specifications

Our Abpromise guarantee covers the use of ab54083 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Western blot

    Blocking - Blocking peptide for Anti-FADD antibody (ab24533)

  • Purity
    > 90 % SDS-PAGE.

  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Preservative: 0.02% Thimerosal (merthiolate)
    Constituents: 0.1% BSA, PBS, pH 7.2

General Info

  • Alternative names
    • FADD
    • FADD protein
    • FADD_HUMAN
    • Fas (TNFRSF6) associated via death domain
    • Fas associated via death domain
    • Fas associating death domain containing protein
    • Fas associating protein
    • Fas associating protein with death domain
    • Fas TNFRSF6 associated via death domain
    • FAS-associated death domain protein
    • FAS-associating death domain-containing protein
    • GIG 3
    • GIG3
    • Growth inhibiting gene 3 protein
    • Growth-inhibiting gene 3 protein
    • H sapiens mRNA for mediator of receptor induced toxicity
    • Mediator of receptor induced toxicity
    • MGC8528
    • MORT 1
    • MORT1
    • Protein FADD
    see all
  • Function
    Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis.
  • Tissue specificity
    Expressed in a wide variety of tissues, except for peripheral blood mononuclear leukocytes.
  • Sequence similarities
    Contains 1 death domain.
    Contains 1 DED (death effector) domain.
  • Domain
    Contains a death domain involved in the binding of the corresponding domain within Fas receptor.
  • Information by UniProt

References

ab54083 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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