Overview

  • Product name
    Anti-FAM126A antibody
  • Description
    Rabbit polyclonal to FAM126A
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse
  • Immunogen

    Recombinant protein fragment corresponding to a region within amino acids 178 and 416 of Human FAM126A (NP_115970).

  • Positive control
    • 293T, A431, H1299 ,HeLa, HepG2, MOLT4 and Raji cell lysates

Properties

Applications

Our Abpromise guarantee covers the use of ab98144 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 58 kDa.

Target

  • Function
    Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane (PubMed:26571211). The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis (PubMed:26571211). FAM126A plays a key role in oligodendrocytes formation, a cell type with expanded plasma membrane that requires generation of PtdIns(4)P (PubMed:26571211). Its role in oligodendrocytes formation probably explains its importance in myelination of the central and peripheral nervous system (PubMed:26571211, PubMed:16951682). May also have a role in the beta-catenin/Lef signaling pathway.
  • Tissue specificity
    Widely expressed. Highest levels in heart, brain, placenta, spleen and testis.
  • Involvement in disease
    Leukodystrophy, hypomyelinating, 5
  • Sequence similarities
    Belongs to the FAM126 family.
  • Cellular localization
    Cytoplasm, cytosol. Cell membrane. Localizes to the cytosol and is recruited to the plasma membrane following interaction with other components of the phosphatidylinositol 4-kinase (PI4K) complex.
  • Information by UniProt
  • Database links
  • Alternative names
    • Down regulated by Ctnnb1 a antibody
    • Down regulated by CTNNB1 protein A antibody
    • Down-regulated by CTNNB1 protein A antibody
    • DRCTNNB1A antibody
    • FAM126A antibody
    • Family with sequence similarity 126 member A antibody
    • HCC antibody
    • HLD5 antibody
    • HYCC1 antibody
    • HYCCI_HUMAN antibody
    • Hyccin antibody
    • Protein FAM126A antibody
    see all

Images

  • Anti-FAM126A antibody (ab98144) at 1/1000 dilution + Raji whole cell lysate at 30 µg

    Predicted band size : 58 kDa

References

ab98144 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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