Overview

  • Product name
  • Description
    Mouse polyclonal to FAM134B
  • Host species
    Mouse
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Cow
  • Immunogen

    Full length protein, corresponding to amino acids 1-356 of Human FAM134B, Isoform 2 (NP_061873.2, UniProt ID: Q9H6L5-2).

  • Positive control
    • FAM134B-transfected 293T cell lysate

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term.
  • Storage buffer
    pH: 7.20
    Constituent: 100% PBS
  • Concentration information loading...
  • Purity
    Protein A purified
  • Clonality
    Polyclonal
  • Isotype
    IgG

Applications

Our Abpromise guarantee covers the use of ab169584 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 39 kDa.

Target

  • Function
    Required for long-term survival of nociceptive and autonomic ganglion neurons.
  • Involvement in disease
    Defects in FAM134B are the cause of hereditary sensory and autonomic neuropathy type 2B (HSAN2B) [MIM:613115]. A form of hereditary sensory and autonomic neuropathy, a genetically and clinically heterogeneous group of disorders characterized by degeneration of dorsal root and autonomic ganglion cells, and by sensory and/or autonomic abnormalities. HSAN2B is an autosomal recessive disorder characterized by impairment of pain, temperature and touch sensation. Onset occurs in the first or second decade, with impaired nociception and progressive mutilating ulceration of the hands and feet with osteomyelitis and acroosteolysis. Amputations of the hands and feet are common. Autonomic dysfunction includes hyperhidrosis, urinary incontinence, and slow pupillary light response.
  • Sequence similarities
    Belongs to the FAM134 family.
  • Cellular localization
    Golgi apparatus > cis-Golgi network membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • F134B_HUMAN antibody
    • FAM134B antibody
    • family with sequence similarity 134 member B antibody
    • HSAN2B antibody
    • JK 1 antibody
    • JK1 antibody
    • Protein FAM134B antibody
    see all

Images

  • All lanes : Anti-FAM134B antibody (ab169584) at 1 µg/ml

    Lane 1 : FAM134B-transfected 293T cell lysate
    Lane 2 : Non-transfected 293T cell lysate

    Lysates/proteins at 15 µl per lane.

    Developed using the ECL technique.

    Predicted band size: 39 kDa

References

ab169584 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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