The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use a concentration of 1 µg/ml. Predicted molecular weight: 318 kDa.
Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.
Use at an assay dependent concentration.
Titre using peptide based assay: 1/312500.
FunctionComponent of a mechanosensitive channel required for rapidly adapting mechanically activated (MA) currents. Required for Merkel-cell mechanotransduction. Plays a major role in light-touch mechanosensation.
Involvement in diseaseArthrogryposis, distal, 5 Arthrogryposis, distal, 3 Marden-Walker syndrome
Sequence similaritiesBelongs to the PIEZO (TC 1.A.75) family.