Anti-FAN1 antibody (ab68572)

Overview

• Product nameAnti-FAN1 antibody
  See all FAN1 primary antibodies
• Description
  Mouse polyclonal to FAN1
• Tested applicationsSuitable for: WBmore details
• Species reactivity
  Reacts with: Human
  
• Immunogen

  Full length human MTMR15 protein (AAH47882, 1 a.a. ~ 533 a.a)

• Positive control
  • Human spleen lysate. MTMR15 transfected 293T cell lysate.

Properties

• FormLiquid
• Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Storage bufferPreservative: None
  Constituents: 1X PBS, pH 7.2
• Concentration information loading...
• PurityProtein A purified
• ClonalityPolyclonal
• IsotypeIgG
• Research areas
  • Epigenetics and Nuclear Signaling
  • DNA / RNA
  • DNA Damage & Repair
  • Fanconi's Anemia

Associated products

• Compatible Secondaries
  • Goat Anti-Mouse IgG H&L (Alexa Fluor® 488) (ab150113)
  • Goat Anti-Mouse IgG H&L (HRP) (ab205719)

Applications

Target

• FunctionNuclease required for maintenance of chromosomal stability. Plays a key role in DNA repair of DNA interstrand cross-links (ICL) by being recruited to sites of DNA damage by monoubiquitinated FANCD2. Specifically involved in repair of ICL-induced DNA breaks by being required for efficient homologous recombination, possibly in the resolution of homologous recombination intermediates. Not involved in DNA double-strand breaks resection. Has both endonuclease activity toward 5'-flaps and 5'-exonuclease activity: may act in concert with the 3'-flap-specific enzymes to unhook the ICL by cleaving the lagging-strand template.
• Sequence similaritiesBelongs to the FAN1 family.
  Contains 1 UBZ-type zinc finger.
  Contains 1 VRR-NUC domain.
• DomainThe UBZ-type zinc finger specifically binds monoubiquitinated FANCD2.
• Cellular localizationNucleus. Localizes at sites of DNA damage following recruitment by monoubiquitinated FANCD2.

• Target information above from: UniProt accession Q9Y2M0 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• Database links
  • Entrez Gene: 22909 Human
  • Omim: 613534 Human
  • SwissProt: Q9Y2M0 Human
  • Unigene: 584863 Human
• Alternative names
  • 6030441H18Rik antibody
  • Coiled coil domain containing protein MTMR15 antibody
  • DKFZp451H236 antibody

  • DKFZp686K16147 antibody
  • FAN1 antibody
  • FAN1_HUMAN antibody
  • FANCD2/FANCI associated nuclease 1 antibody
  • FANCD2/FANCI-associated nuclease 1 antibody
  • Fanconi associated nuclease 1 antibody
  • Fanconi-associated nuclease 1 antibody
  • KIAA1018 antibody
  • MTMR 15 antibody
  • MTMR15 antibody
  • Myotubularin related protein 15 antibody
  • Myotubularin-related protein 15 antibody

  see all