Overview

  • Product nameAnti-FANCB antibody
    See all FANCB primary antibodies
  • Description
    Mouse polyclonal to FANCB
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Full length protein (Human), (NP_001018123).

  • Positive control
    • FANCB transfected 293T cell lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab72810 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Predicted molecular weight: 98 kDa.

Target

  • FunctionDNA repair protein required for FANCD2 ubiquitination.
  • Involvement in diseaseDefects in FANCB are the cause of Fanconi anemia complementation group B (FANCB) [MIM:300514]. It is a disorder affecting all bone marrow elements and resulting in anemia, leukopenia and thrombopenia. It is associated with cardiac, renal and limb malformations, dermal pigmentary changes, and a predisposition to the development of malignancies. At the cellular level it is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased chromosome breakage) and defective DNA repair.
    Defects in FANCB are the cause of X-linked VACTERL-H (XVACTERL-H) [MIM:314390]; also known as X-linked VACTERL association with hydrocephalus syndrome. VACTERL is an acronym for vertebral anomalies, anal atresia, cardiac malformations, tracheoesophageal fistula, renal anomalies (urethral atresia with hydronephrosis), and limb anomalies (hexadactyly, humeral hypoplasia, radial aplasia, and proximally placed thumb). Some cases of VACTERL-H are associated with increased chromosome breakage and rearrangement.
  • Cellular localizationNucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • FA2 antibody
    • FAAP90 antibody
    • FAAP95 antibody
    • FAB antibody
    • FACB antibody
    • Fancb antibody
    • FANCB_HUMAN antibody
    • Fanconi anemia associated polypeptide of 95 kDa antibody
    • Fanconi anemia group B protein antibody
    • Fanconi anemia, complementation group B antibody
    • Fanconi anemia-associated polypeptide of 95 kDa antibody
    • Protein FACB antibody
    see all

Anti-FANCB antibody images

  • All lanes : Anti-FANCB antibody (ab72810) at 1/500 dilution

    Lane 1 : FANCB transfected 293T cell lysate
    Lane 2 : Untransfected 293T cell lysate

    Lysates/proteins at 25 µg per lane.

    Secondary
    Goat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution
    Developed using the ECL technique

    Predicted band size : 98 kDa
    Observed band size : 105 kDa (why is the actual band size different from the predicted?)

References for Anti-FANCB antibody (ab72810)

ab72810 has not yet been referenced specifically in any publications.

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