Overview

  • Product name
  • Description
    Rabbit polyclonal to FANCC
  • Tested applications
    Suitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide corresponding to a region within N terminal amino acids 529-558 of Human FANCC (UniProt ID: Q00597) conjugated to KLH.

  • Positive control
    • HepG2 cell line lysates; Human testis tissue

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Store at 4°C (up to 6 months). Store at -20°C long term.
  • Storage buffer
    Preservative: 0.09% Sodium Azide
    Constituents: PBS
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Purification notes
    ab102788 is purified through a protein A column, followed by peptide affinity purification.
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab102788 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/500. Predicted molecular weight: 63 kDa.
IHC-P 1/50 - 1/100. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • Function
    DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1.
  • Tissue specificity
    Ubiquitous.
  • Involvement in disease
    Defects in FANCC are the cause of Fanconi anemia complementation group C (FANCC) [MIM:227645]. A disorder affecting all bone marrow elements and resulting in anemia, leukopenia and thrombopenia. It is associated with cardiac, renal and limb malformations, dermal pigmentary changes, and a predisposition to the development of malignancies. At the cellular level it is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased chromosome breakage) and defective DNA repair.
  • Developmental stage
    Expression increases during S phase, is maximal at the G2/M transition, and declines during M phase (at protein level).
  • Cellular localization
    Nucleus. Cytoplasm. The major form is nuclear. The minor form is cytoplasmic.
  • Information by UniProt
  • Database links
  • Alternative names
    • bA80I15.1 antibody
    • FA 3 antibody
    • FA3 antibody
    • FAC antibody
    • FACC antibody
    • FANCC antibody
    • FANCC_HUMAN antibody
    • Fanconi anemia complementation group C antibody
    • Fanconi anemia complementation group C protein antibody
    • Fanconi anemia group C protein antibody
    • Fanconi pancytopenia type 3 antibody
    • FLJ14675 antibody
    • Protein FACC antibody
    see all

Images

  • Anti-FANCC antibody (ab102788) at 1/100 dilution + HepG2 cell line lysates at 35 µg

    Predicted band size : 63 kDa
  • ab102788, at a 1/50 dilution, staining FANCC in formalin fixed, paraffin embedded Human testis by Immunohistochemistry, followed by peroxidase conjugated secondary antibody and DAB staining.

References

ab102788 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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