Overview

  • Product name
  • Description
    Rabbit polyclonal to FANCE
  • Tested applications
    Suitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant fragment, corresponding to a region within amino acids 205-442 of Human FANCE (Q9HB96).

  • Positive control
    • HeLa, HepG2 and HCT116 whole cell lysates; Human breast carcinoma tissue.

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage buffer
    pH: 7.00
    Preservative: 0.01% Thimerosal (merthiolate)
    Constituents: 78% PBS, 20% Glycerol, 1% BSA
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab126177 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 58 kDa.
IHC-P 1/100 - 1/500. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • Function
    As part of the Fanconi anemia (FA) complex functions in DNA cross-links repair. Required for the nuclear accumulation of FANCC and provides a critical bridge between the FA complex and FANCD2.
  • Involvement in disease
    Fanconi anemia complementation group E
  • Post-translational
    modifications
    Phosphorylated. Phosphorylation by CHEK1 at Thr-346 and Ser-374 regulates its function in DNA cross-links repair.
    Ubiquitinated. Phosphorylation by CHEK1 induces polyubiquitination and degradation.
  • Cellular localization
    Nucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • 2810451D06Rik antibody
    • AI415634 antibody
    • AW209126 antibody
    • FACE antibody
    • FAE antibody
    • FANCE antibody
    • FANCE_HUMAN antibody
    • Fanconi anemia complementation group E antibody
    • Fanconi anemia group E protein antibody
    • OTTHUMP00000016254 antibody
    • Protein FACE antibody
    • RGD1561045 antibody
    see all

Images

  • Anti-FANCE antibody (ab126177) at 1/1000 dilution + HepG2 whole cell lysate at 30 µg

    Predicted band size : 58 kDa
  • ab126177, at 1/250 dilution, staining FANCE in paraffin-embedded Human breast carcinoma tissue.

References

ab126177 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab126177.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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