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Rabbit polyclonal to FANCE
Recombinant fragment, corresponding to a region within amino acids 205-442 of Human FANCE (Q9HB96).
- HeLa, HepG2 and HCT116 whole cell lysates; Human breast carcinoma tissue.
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 78% PBS, 20% Glycerol, 1% BSA
Concentration information loading...
Immunogen affinity purified
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in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
||1/500 - 1/3000. Predicted molecular weight: 58 kDa.
||1/100 - 1/500. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
As part of the Fanconi anemia (FA) complex functions in DNA cross-links repair. Required for the nuclear accumulation of FANCC and provides a critical bridge between the FA complex and FANCD2.
Involvement in disease
Fanconi anemia complementation group E
Phosphorylated. Phosphorylation by CHEK1 at Thr-346 and Ser-374 regulates its function in DNA cross-links repair.
Ubiquitinated. Phosphorylation by CHEK1 induces polyubiquitination and degradation.
Information by UniProt
- 2810451D06Rik antibody
- AI415634 antibody
- AW209126 antibody
Western blot - FANCE antibody (ab126177)
Anti-FANCE antibody (ab126177) at 1/1000 dilution + HepG2 whole cell lysate at 30 µg
Predicted band size: 58 kDa
7.5% SDS PAGE
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - FANCE antibody (ab126177)
ab126177, at 1/250 dilution, staining FANCE in paraffin-embedded Human breast carcinoma tissue.
has not yet been referenced specifically in any publications.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"