Overview

  • Product name
  • Description
    Goat polyclonal to FANCG
  • Tested applications
    Suitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Dog, Rhesus monkey
  • Immunogen

    Synthetic peptide:

    LEEFRTSLPKSCDL

    , corresponding to C terminal amino acids 609 - 622 of Human FANCG (O15287)

  • Positive control
    • Huamn spleen and uterus tissue HeLa cell lysate

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
  • Storage buffer
    pH: 7.30
    Preservative: 0.02% Sodium azide
    Constituents: 0.5% BSA, 99% Tris buffered saline
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab115230 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.5 - 1 µg/ml. Predicted molecular weight: 69 kDa.
IHC-P Use a concentration of 3 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • Function
    DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Candidate tumor suppressor gene.
  • Tissue specificity
    Highly expressed in testis and thymus. Found in lymphoblasts.
  • Involvement in disease
    Defects in FANCG are a cause of Fanconi anemia (FA) [MIM:227650]. FA is a genetically heterogeneous, autosomal recessive disorder characterized by progressive pancytopenia, a diverse assortment of congenital malformations, and a predisposition to the development of malignancies. At the cellular level it is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased chromosome breakage), and defective DNA repair.
  • Sequence similarities
    Contains 4 TPR repeats.
  • Cellular localization
    Nucleus. Cytoplasm. The major form is nuclear. The minor form is cytoplasmic.
  • Information by UniProt
  • Database links
  • Alternative names
    • DNA repair protein XRCC9 antibody
    • FAG antibody
    • FANCG antibody
    • FANCG_HUMAN antibody
    • Fanconi anaemia complementation group G antibody
    • Fanconi anemia group G protein antibody
    • Protein FACG antibody
    • X ray repair, complementing defective, in Chinese hamster cells 9 antibody
    • X-ray repair, complementing defective, in Chinese hamster, 9 antibody
    • XRCC9 antibody
    see all

Anti-FANCG antibody images

  • Anti-FANCG antibody (ab115230) at 0.5 µg/ml + HeLa cell lysate (in RIPA buffer) at 35 µg
    Developed using the ECL technique

    Predicted band size : 69 kDa
  • ab115230 at 3 ug/ml, staining FANCG in Formalin-fixed, Paraffin-embedded Human spleen tissue by Immunohistochemistry followed by biotinylated secondary antibody, alkaline phosphatase-streptavidin and chromogen.
  • ab115230 at 3 ug/ml, staining FANCG in Formalin-fixed, Paraffin-embedded Human uterus tissue by Immunohistochemistry followed by biotinylated secondary antibody, alkaline phosphatase-streptavidin and chromogen.

References for Anti-FANCG antibody (ab115230)

ab115230 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab115230.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

Sign up