Overview

  • Product name
  • Description
    Goat polyclonal to FANCG
  • Tested applications
    Suitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Dog, Rhesus monkey
  • Immunogen

    Synthetic peptide:

    LEEFRTSLPKSCDL

    , corresponding to C terminal amino acids 609 - 622 of Human FANCG (O15287)

  • Positive control
    • Huamn spleen and uterus tissue HeLa cell lysate

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
  • Storage buffer
    pH: 7.30
    Preservative: 0.02% Sodium azide
    Constituents: 0.5% BSA, 99% Tris buffered saline
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab115230 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.5 - 1 µg/ml. Predicted molecular weight: 69 kDa.
IHC-P Use a concentration of 3 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • Function
    DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Candidate tumor suppressor gene.
  • Tissue specificity
    Highly expressed in testis and thymus. Found in lymphoblasts.
  • Involvement in disease
    Defects in FANCG are a cause of Fanconi anemia (FA) [MIM:227650]. FA is a genetically heterogeneous, autosomal recessive disorder characterized by progressive pancytopenia, a diverse assortment of congenital malformations, and a predisposition to the development of malignancies. At the cellular level it is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased chromosome breakage), and defective DNA repair.
  • Sequence similarities
    Contains 4 TPR repeats.
  • Cellular localization
    Nucleus. Cytoplasm. The major form is nuclear. The minor form is cytoplasmic.
  • Information by UniProt
  • Database links
  • Alternative names
    • DNA repair protein XRCC9 antibody
    • FAG antibody
    • FANCG antibody
    • FANCG_HUMAN antibody
    • Fanconi anaemia complementation group G antibody
    • Fanconi anemia group G protein antibody
    • Protein FACG antibody
    • X ray repair, complementing defective, in Chinese hamster cells 9 antibody
    • X-ray repair, complementing defective, in Chinese hamster, 9 antibody
    • XRCC9 antibody
    see all

Images

  • Anti-FANCG antibody (ab115230) at 0.5 µg/ml + HeLa cell lysate (in RIPA buffer) at 35 µg
    Developed using the ECL technique

    Predicted band size : 69 kDa
  • ab115230 at 3 ug/ml, staining FANCG in Formalin-fixed, Paraffin-embedded Human spleen tissue by Immunohistochemistry followed by biotinylated secondary antibody, alkaline phosphatase-streptavidin and chromogen.
  • ab115230 at 3 ug/ml, staining FANCG in Formalin-fixed, Paraffin-embedded Human uterus tissue by Immunohistochemistry followed by biotinylated secondary antibody, alkaline phosphatase-streptavidin and chromogen.

References

ab115230 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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