Overview

  • Product name
  • Description
    Rabbit polyclonal to FANCG
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide:

    MSRQTTSVGSSC

    , corresponding to amino acids 1 - 12 of Human FANCG.

  • General notes
    Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of opening.

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage buffer
    pH: 7.20
    Preservative: 0.01% Sodium azide
    Constituents: 0.424% Potassium phosphate, 0.878% Sodium chloride
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab5067 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500. Detects a band of approximately 69 kDa (predicted molecular weight: 69 kDa).

Target

  • Function
    DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Candidate tumor suppressor gene.
  • Tissue specificity
    Highly expressed in testis and thymus. Found in lymphoblasts.
  • Involvement in disease
    Defects in FANCG are a cause of Fanconi anemia (FA) [MIM:227650]. FA is a genetically heterogeneous, autosomal recessive disorder characterized by progressive pancytopenia, a diverse assortment of congenital malformations, and a predisposition to the development of malignancies. At the cellular level it is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased chromosome breakage), and defective DNA repair.
  • Sequence similarities
    Contains 4 TPR repeats.
  • Cellular localization
    Nucleus. Cytoplasm. The major form is nuclear. The minor form is cytoplasmic.
  • Information by UniProt
  • Database links
  • Alternative names
    • DNA repair protein XRCC9 antibody
    • FAG antibody
    • FANCG antibody
    • FANCG_HUMAN antibody
    • Fanconi anaemia complementation group G antibody
    • Fanconi anemia group G protein antibody
    • Protein FACG antibody
    • X ray repair, complementing defective, in Chinese hamster cells 9 antibody
    • X-ray repair, complementing defective, in Chinese hamster, 9 antibody
    • XRCC9 antibody
    see all

Images

  • Anti-FANCG antibody (ab5067) at 1/500 dilution + HeLa whole cell lysate at 35 µg

    Secondary
    IRDye 800 conjugated Goat anti-Rabbit IgG [H&L] at 1/10000 dilution

    Performed under reducing conditions.

    Predicted band size : 69 kDa
    Observed band size : 69 kDa
    Additional bands at : 11 kDa,24 kDa. We are unsure as to the identity of these extra bands.

References

This product has been referenced in:
  • Song ZP  et al. Minocycline attenuates bone cancer pain in rats by inhibiting NF-?B in spinal astrocytes. Acta Pharmacol Sin 37:753-62 (2016). Read more (PubMed: 27157092) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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