Anti-FANCL antibody - C-terminal (ab174210)

Overview

  • Product name
    Anti-FANCL antibody - C-terminal
    See all FANCL primary antibodies
  • Description
    Rabbit polyclonal to FANCL - C-terminal
  • Host species
    Rabbit
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide within Human FANCL aa 274-302 (C terminal) conjugated to Keyhole Limpet Haemocyanin (KLH). The exact sequence is proprietary. (NP_001108108.1)
    Database link: Q9NW38

  • Positive control
    • 293 cell line lysate

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer
    Preservative: 0.09% Sodium azide
    Constituent: 99% PBS
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Purification notes
    ab174210 was purified through a protein A column, followed by peptide affinity purification.
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab174210 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/500. Predicted molecular weight: 42 kDa.

Target

  • Function
    Ubiquitin ligase protein that mediates monoubiquitination of FANCD2, a key step in the DNA damage pathway. Also mediates monoubiquitination of FANCI. May stimulate the ubiquitin release from UBE2W. May be required for proper primordial germ cell proliferation in the embryonic stage, whereas it is probably not needed for spermatogonial proliferation after birth.
  • Pathway
    Protein modification; protein ubiquitination.
  • Involvement in disease
    Fanconi anemia complementation group L
  • Sequence similarities
    Contains 1 RING-type zinc finger.
  • Domain
    The UBC-RWD region (URD) region mediates interaction with FANCI and FANCD2.
  • Post-translational
    modifications
    The RING-type zinc finger domain is monoubiquitinated in the presence of UBE2T and UBE2W.
  • Cellular localization
    Cytoplasm. Nucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • E3 ubiquitin-protein ligase FANCL antibody
    • FAAP43 antibody
    • Fancl antibody
    • FANCL_HUMAN antibody
    • Fanconi anemia complementation group L antibody
    • Fanconi anemia group L protein antibody
    • Fanconi anemia-associated polypeptide of 43 kDa antibody
    • FLJ10335 antibody
    • PHD finger protein 9 antibody
    • PHF9 antibody
    • POG antibody
    • Ubiquitin ligase protein FANCL antibody
    see all

Images

  • Anti-FANCL antibody - C-terminal (ab174210) at 1/100 dilution + 293 cell line lysate at 35 µg

    Predicted band size: 42 kDa

References

ab174210 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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