Overview

  • Product nameAnti-Fas antibody [B-D29]See all Fas primary antibodies ...
  • Description
    Mouse monoclonal [B-D29] to Fas
  • Tested applicationsFunctional Studiesmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant full length protein corresponding to Human Fas. Recombinant full length protein (Human) - purified Fas antigen.

Properties

Applications

Our Abpromise guarantee covers the use of ab34359 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Functional Studies
  • Application notesFuncS: Use at an assay dependent dilution.
    ab34359 can be used for Biological studies.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionReceptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro).
    • Tissue specificityIsoform 1 and isoform 6 are expressed at equal levels in resting peripheral blood mononuclear cells. After activation there is an increase in isoform 1 and decrease in the levels of isoform 6.
    • Involvement in diseaseDefects in FAS are the cause of autoimmune lymphoproliferative syndrome type 1A (ALPS1A) [MIM:601859]; also known as Canale-Smith syndrome (CSS). ALPS is a childhood syndrome involving hemolytic anemia and thrombocytopenia with massive lymphadenopathy and splenomegaly.
    • Sequence similaritiesContains 1 death domain.
      Contains 3 TNFR-Cys repeats.
    • DomainContains a death domain involved in the binding of FADD, and maybe to other cytosolic adapter proteins.
    • Cellular localizationSecreted and Cell membrane.
    • Information by UniProt
    • Database links
    • Alternative names
      • ALPS 1A antibody
      • ALPS1A antibody
      • APO 1 antibody
      • Apo 1 antigen antibody
      • APO 1 cell surface antigen antibody
      • Apo-1 antigen antibody
      • APO1 antibody
      • Apo1 antigen antibody
      • APO1 cell surface antigen antibody
      • Apoptosis antigen 1 antibody
      • Apoptosis APO1 antigen 1 antibody
      • Apoptosis mediating surface antigen FAS antibody
      • Apoptosis-mediating surface antigen FAS antibody
      • APT 1 antibody
      • APT1 antibody
      • APT1 antibody
      • CD 95 antibody
      • CD 95 antigen antibody
      • CD95 antibody
      • CD95 antigen antibody
      • Delta Fas antibody
      • Delta Fas/APO 1/CD95 antibody
      • Delta Fas/APO1/CD95 antibody
      • Fas (TNF receptor superfamily member 6) antibody
      • Fas (TNF receptor superfamily, member 6) antibody
      • FAS 1 antibody
      • FAS 827dupA antibody
      • Fas AMA antibody
      • FAS antibody
      • FAS Antigen antibody
      • FAS Antigen antibody
      • Fas cell surface death receptor antibody
      • FAS1 antibody
      • FASL receptor antibody
      • FASLG receptor antibody
      • FASTM antibody
      • sFAS antibody
      • Surface antigen APO1 antibody
      • TNF receptor superfamily member 6 antibody
      • TNF receptor superfamily, member 6 antibody
      • TNFR6 antibody
      • TNFRSF 6 antibody
      • TNFRSF6 antibody
      • TNFRSF6 antibody
      • TNR6_HUMAN antibody
      • Tumor necrosis factor receptor superfamily member 6 antibody
      see all

    References for Anti-Fas antibody [B-D29] (ab34359)

    This product has been referenced in:
    • Ferraro C  et al. The topoisomerase inhibitors camptothecin and etoposide induce a CD95-independent apoptosis of activated peripheral lymphocytes. Cell Death Differ 7:197-206 (2000). Read more (PubMed: 10713734) »

    See 1 Publication for this product

    Product Wall

    Thank you for contacting us. ab19456, ab11881, ab34359, ab25405 and ab25290 antibodies can be used in Biological studies which may include apoptosis. We unfortunately haven’t tested these antibodies in our own laboratory so unfortunately we will no...

    Read More

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"