Overview

  • Product name
    Fascaplysin
  • Description
    Potent, selective ATP-competitve CDK4 inhibitor
  • Biological description
    Potent, selective ATP-competitive CDK4 inhibitor (IC50 = 350 nM). Suppresses VEGF expression and inhibits endothelial cell proliferation. Induces apoptosis and cytotoxic autophagy in vitro.

Properties

  • Molecular weight
    306.75
  • Chemical structure
    Chemical Structure
  • Molecular formula
    C18H11ClN2O
  • CAS Number
    114719-57-2
  • Storage instructions
    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES
    [Cl-].O=C4c1ccccc1[n+]5ccc2c(nc3ccccc23)c45
  • Source

    Synthetic

References

This product has been referenced in:
  • Kumar S  et al. Fascaplysin induces caspase mediated crosstalk between apoptosis and autophagy through the inhibition of PI3K/AKT/mTOR signaling cascade in human leukemia HL-60 cells. J Cell Biochem 116:985-97 (2015). Read more (PubMed: 25561006) »
  • Mahale S  et al. Antitumour potential of BPT: a dual inhibitor of cdk4 and tubulin polymerization. Cell Death Dis 6:e1743 (2015). Read more (PubMed: 25950473) »
  • Lin J  et al. Fascaplysin, a selective CDK4 inhibitor, exhibit anti-angiogenic activity in vitro and in vivo. Cancer Chemother Pharmacol 59:439-45 (2007). Read more (PubMed: 16816972) »

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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