Overview

  • Product nameAnti-Fascin 2 antibody
    See all Fascin 2 primary antibodies
  • Description
    Goat polyclonal to Fascin 2
  • Specificityab78599 is expected to recognize both reported isoforms (NP_001070650.1 and NP_036550.1) of Fascin 2.
  • Tested applicationsSuitable for: ICC/IF, WBmore details
  • Species reactivity
    Reacts with: Mouse
    Predicted to work with: Rat, Cow, Dog, Human
  • Immunogen

    Synthetic peptide:

    CHHRGSNQLDTNR

    , corresponding to internal sequence amino acids of Human Fascin 2 (NP_001070650.1 and NP_036550.1)

  • Positive control
    • Mouch cochlea.

Properties

Applications

Our Abpromise guarantee covers the use of ab78599 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ICC/IF Use at an assay dependent concentration.
WB Use at an assay dependent concentration. Preliminary experiments gave bands at approx 75kDa and 22kDa in Mouse Eye lysates after 0.05µg/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the bands we observe. Both detected bands were successfully blocked by incubation with the immunizing peptide (and BLAST results with the immunizing peptide sequence did not identify any other proteins to explain the additional bands).

Target

  • FunctionActs as an actin bundling protein. May play a pivotal role in photoreceptor cell-specific events, such as disk morphogenesis.
  • Tissue specificityLocalized specifically in the outer and inner segments of the photoreceptor cells in the retina.
  • Involvement in diseaseDefects in FSCN2 are the cause of retinitis pigmentosa type 30 (RP30) [MIM:607921]. RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. RP30 inheritance is autosomal dominant.
  • Sequence similaritiesBelongs to the fascin family.
  • Cellular localizationCytoplasm > cytoskeleton. Cell projection > stereocilium.
  • Information by UniProt
  • Database links
  • Alternative names
    • Fascin homolog 2, actin bundling protein, retinal Strongylocentrotus purpuratus antibody
    • Fascin Strongylocentrotus purpuratus homolog 2 actin bundling protein, retinal antibody
    • Fascin-2 antibody
    • FSCN2 antibody
    • FSCN2_HUMAN antibody
    • Retinal fascin antibody
    • RFSN antibody
    • RP30 antibody
    see all

References for Anti-Fascin 2 antibody (ab78599)

ab78599 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"