FunctionOrganizes filamentous actin into bundles with a minimum of 4.1:1 actin/fascin ratio. Plays a role in the organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers. Important for the formation of a diverse set of cell protrusions, such as filopodia, and for cell motility and migration.
Sequence similaritiesBelongs to the fascin family.
DomainComposed of four beta-trefoil domains.
Post-translational modificationsPhosphorylation on Ser-39 inhibits the actin-binding ability of fascin.
Fascin homolog 1 actin bundling protein (Strongylocentrotus purpuratus) antibody
Fascin homolog 1 antibody
Fascin, sea urchin, homolog of, 1 antibody
FSCN 1 antibody
Singed (Drosophila) like (sea urchin fascin homolog like) antibody
Singed drosophila homolog like antibody
Singed like (fascin homolog sea urchin) (Drosophila) antibody
Singed like (fascin homolog sea urchin) antibody
Singed like protein antibody
Singed, drosophila, homolog of antibody
Singed-like protein antibody
Strongylocentrotus purpuratus antibody
Anti-Fascin antibody images
Western blot - Anti-Fascin antibody (ab97753)
All lanes : Anti-Fascin antibody (ab97753) at 1/1000 dilution
Lane 1 : HeLa whole cell lysate Lane 2 : HepG2 whole cell lysate
Lysates/proteins at 30 µg per lane.
Predicted band size : 55 kDa
References for Anti-Fascin antibody (ab97753)
This product has been referenced in:
Qian CJ et al. Notch4 inhibition reduces migration and invasion and enhances sensitivity to docetaxel by inhibiting Akt/fascin in pancreatic cancer cells. Oncol Lett12:3499-3505 (2016).
Read more (PubMed: 27900027) »