Recombinant
RabMAb

Anti-Fascin antibody [EPR2681] (ab108607)

Overview

  • Product name
    Anti-Fascin antibody [EPR2681]
    See all Fascin primary antibodies
  • Description
    Rabbit monoclonal [EPR2681] to Fascin
  • Tested applications
    Suitable for: WB, Flow Cytmore details
    Unsuitable for: ICC,IHC-P or IP
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide, corresponding to internal sequence amino acids 435-460 of Human Fascin

  • Positive control
    • HeLa, SH-SY5Y and K-562 cell lysates
  • General notes

    This product is a recombinant rabbit monoclonal antibody.

    Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents

Properties

Applications

Our Abpromise guarantee covers the use of ab108607 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/10000. Predicted molecular weight: 55 kDa.
Flow Cyt 1/500 - 1/1000. ab172730-Rabbit monoclonal IgG, is suitable for use as an isotype control with this antibody.
  • Application notes
    Is unsuitable for ICC,IHC-P or IP.
  • Target

    • Function
      Organizes filamentous actin into bundles with a minimum of 4.1:1 actin/fascin ratio. Plays a role in the organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers. Important for the formation of a diverse set of cell protrusions, such as filopodia, and for cell motility and migration.
    • Tissue specificity
      Ubiquitous.
    • Sequence similarities
      Belongs to the fascin family.
    • Domain
      Composed of four beta-trefoil domains.
    • Post-translational
      modifications
      Phosphorylation on Ser-39 inhibits the actin-binding ability of fascin.
    • Cellular localization
      Cytoplasm > cytoskeleton. Cell projection > filopodium. Cell projection > invadopodium.
    • Information by UniProt
    • Database links
    • Alternative names
      • 55 kDa actin bundling protein antibody
      • 55 kDa actin-bundling protein antibody
      • Actin bundling protein antibody
      • actin bundling protein, 55-KD antibody
      • FAN 1 antibody
      • FAN1 antibody
      • Fascin 1 antibody
      • Fascin actin bundling protein 1 antibody
      • Fascin antibody
      • Fascin homolog 1 actin bundling protein (Strongylocentrotus purpuratus) antibody
      • Fascin homolog 1 antibody
      • Fascin, sea urchin, homolog of, 1 antibody
      • Fascin1 antibody
      • FLJ38511 antibody
      • FSCN 1 antibody
      • FSCN1 antibody
      • FSCN1_HUMAN antibody
      • HSN antibody
      • p55 antibody
      • Singed (Drosophila) like (sea urchin fascin homolog like) antibody
      • Singed drosophila homolog like antibody
      • Singed like (fascin homolog sea urchin) (Drosophila) antibody
      • Singed like (fascin homolog sea urchin) antibody
      • Singed like protein antibody
      • Singed, drosophila, homolog of antibody
      • Singed-like protein antibody
      • SNL antibody
      • Strongylocentrotus purpuratus antibody
      see all

    Images

    • All lanes : Anti-Fascin antibody [EPR2681] (ab108607) at 1/1000 dilution

      Lane 1 : HeLa cell lysate
      Lane 2 : SH-SY5Y cell lysate
      Lane 3 : K562 cell lysate

      Lysates/proteins at 10 µg per lane.

      Secondary
      HRP labelled goat anti-rabbit at 1/2000 dilution

      Predicted band size : 55 kDa
    • Equilibrium disassociation constant (KD)
      Learn more about KD

      Click here to learn more about KD

    References

    ab108607 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As

    There are currently no Customer reviews or Questions for ab108607.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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