Anti-Fascin (phospho S39) antibody (ab90618)
Key features and details
- Rabbit polyclonal to Fascin (phospho S39)
- Suitable for: IHC-P, ICC/IF, WB
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-Fascin (phospho S39) antibody
See all Fascin primary antibodies -
Description
Rabbit polyclonal to Fascin (phospho S39) -
Host species
Rabbit -
Tested applications
Suitable for: IHC-P, ICC/IF, WBmore details -
Species reactivity
Reacts with: Human
Predicted to work with: Mouse, Rat -
Immunogen
Synthetic peptide corresponding to Human Fascin (N terminal) (phospho S39).
Database link: Q16658 -
General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C. Avoid freeze / thaw cycle. -
Storage buffer
Constituent: Whole serum -
Concentration information loading...
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Purity
Whole antiserum -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab90618 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
---|---|---|
IHC-P | (1) |
Use at an assay dependent concentration.
|
ICC/IF |
Use at an assay dependent concentration.
|
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WB |
Use at an assay dependent concentration.
|
Notes |
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IHC-P
Use at an assay dependent concentration. |
ICC/IF
Use at an assay dependent concentration. |
WB
Use at an assay dependent concentration. |
Target
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Function
Organizes filamentous actin into bundles with a minimum of 4.1:1 actin/fascin ratio. Plays a role in the organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers. Important for the formation of a diverse set of cell protrusions, such as filopodia, and for cell motility and migration. -
Tissue specificity
Ubiquitous. -
Sequence similarities
Belongs to the fascin family. -
Domain
Composed of four beta-trefoil domains. -
Post-translational
modificationsPhosphorylation on Ser-39 inhibits the actin-binding ability of fascin. -
Cellular localization
Cytoplasm > cytoskeleton. Cell projection > filopodium. Cell projection > invadopodium. - Information by UniProt
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Database links
- Entrez Gene: 6624 Human
- Entrez Gene: 14086 Mouse
- Entrez Gene: 683788 Rat
- Omim: 602689 Human
- SwissProt: Q16658 Human
- SwissProt: Q61553 Mouse
- SwissProt: P85845 Rat
- Unigene: 118400 Human
see all -
Alternative names
- 55 kDa actin bundling protein antibody
- 55 kDa actin-bundling protein antibody
- Actin bundling protein antibody
see all
Protocols
Datasheets and documents
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Datasheet download
References (2)
ab90618 has been referenced in 2 publications.
- Fan YL et al. A function of fascin1 in the colony formation of mouse embryonic stem cells. Stem Cells N/A:N/A (2020). PubMed: 32379912
- Giza JI et al. The BDNF Val66Met Prodomain Disassembles Dendritic Spines Altering Fear Extinction Circuitry and Behavior. Neuron 99:163-178.e6 (2018). PubMed: 29909994