Anti-FAT antibody [Fat-1] (ab20163)

Overview

  • Product nameAnti-FAT antibody [Fat-1]
    See all FAT primary antibodies
  • Description
    Mouse monoclonal [Fat-1] to FAT
  • Tested applicationsSuitable for: WB, ICC/IF, ELISAmore details
  • Species reactivity
    Reacts with: Drosophila melanogaster
    Predicted to work with: Rat, Chimpanzee
  • Immunogen

    Cytoplasmic domain of drosphila FAT 1

  • Positive control
    • Wild type imaginal discs from third instar larva

Properties

Applications

Our Abpromise guarantee covers the use of ab20163 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
ICC/IF
ELISA
  • Application notesELISA: Use at an assay dependent dilution.
    IF: Use at an assay dependent dilution.
    WB: Use 3-8% gradient gels to visualise the FAT protein and wet transfer. Predicted molecular weight: 506 kDa.

    Not tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionPlays an essential role for cellular polarization, directed cell migration and modulating cell-cell contact.
    • Tissue specificityExpressed in many epithelial and some endothelial and smooth muscle cells.
    • Sequence similaritiesContains 33 cadherin domains.
      Contains 5 EGF-like domains.
      Contains 1 laminin G-like domain.
    • DomainA PTB-like motif (DNXYH sequence) is required for the targeting to the leading edge. This motif represents a minimal protein-protein interaction core motif that is not regulated by tyrosine phosphorylation.
    • Post-translational
      modifications
      Undergoes proteolytic cleavage. The extracellular domain is cleaved off and the cytoplasmic domain (about 400 AA) shuttles to the nucleus.
    • Cellular localizationCell membrane. Nucleus. Cytoplasm > perinuclear region.
    • Information by UniProt
    • Database links
    • Alternative names
      • Cadherin family member 7 antibody
      • Cadherin family member 7 precursor antibody
      • Cadherin ME5 antibody
      • Cadherin related tumor suppressor antibody
      • Cadherin related tumor suppressor homolog antibody
      • Cadherin related tumor suppressor homolog precursor antibody
      • Cadherin related tumor suppressor homolog precursor (FAT protein homolog) antibody
      • Cadherin-related tumor suppressor homolog antibody
      • CDHF 7 antibody
      • CDHF7 antibody
      • FAT 1 antibody
      • FAT tumor suppressor 1 antibody
      • FAT tumor suppressor homolog 1 antibody
      • FAT1 antibody
      • FAT1_HUMAN antibody
      • hFat 1 antibody
      • hFAT antibody
      • hFat1 antibody
      • Homolog of Drosophila FAT protein antibody
      • Homolog of Drosophila FAT protein precursor antibody
      • Homolog of Drosophila tumor suppressor FAT precursor antibody
      • ME 5 antibody
      • ME5 antibody
      • nuclear form antibody
      • Protein fat homolog antibody
      • Protocadherin Fat 1 antibody
      see all

    References for Anti-FAT antibody [Fat-1] (ab20163)

    ab20163 has not yet been referenced specifically in any publications.

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    Thank you for contacting us. This product has not been tested in human. I hope this information is helpful to you. Please do not hesitate to contact us if you need any more advice or information.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"