Anti-FBP17 antibody (ab23934)

Overview

• Product name
  Anti-FBP17 antibody
  See all FBP17 primary antibodies
• Description
  Goat polyclonal to FBP17
• Tested applications
  Suitable for: ELISA, WBmore details
• Species reactivity
  Reacts with: Human
  Predicted to work with: Mouse, Rat, Rabbit, Zebrafish
• Immunogen

  Synthetic peptide:

  KQLESSKRRFERDC

  , corresponding to amino acids 132 - 145 of Human FBP17.

  Run BLAST with Run BLAST with
• Positive control
  • Human Testis lysate.

Properties

• Form
  Liquid
• Storage instructions
  Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Storage buffer
  Preservative: 0.02% Sodium Azide
  Constituents: 0.5% BSA, Tris buffered saline. pH 7.3
• Concentration information loading...
• Purity
  Immunogen affinity purified
• Purification notes
  Purified by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
• Clonality
  Polyclonal
• Isotype
  IgG
• Research areas
  • Signal Transduction
  • Protein Trafficking
  • Vesicle Transport
  • Coat Proteins

Associated products

• Compatible Secondaries
  • Donkey Anti-Goat IgG H&L (Alexa Fluor® 488) (ab150129)
  • Donkey Anti-Goat IgG H&L (HRP) (ab205723)

Applications

Target

• Function
  May act as a link between RND2 signaling and regulation of the actin cytoskeleton (By similarity). Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also enhances actin polymerization via the recruitment of WASL/N-WASP, which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. May be required for the lysosomal retention of FASLG/FASL.
• Tissue specificity
  Very highly expressed in the epithelial cells of the gastrointestinal tract, respiratory, reproductive and urinary systems. Also highly expressed in brown adipose tissue, cardiomyocytes, enteric ganglia and glucagon producing cells of the pancreas. Expressed in germ cells of the testis and all regions of the brain.
• Involvement in disease
  Note=A chromosomal aberration involving FNBP1 is found in acute leukemias. Translocation t(9;11)(q34;q23) with MLL. The relatively low incidence of the MLL-FNBP1 fusion protein in acute leukemia may reflect the marginal capacity of this fusion protein to induce cellular transformation.
• Sequence similarities
  Belongs to the FNBP1 family.
  Contains 1 FCH domain.
  Contains 1 REM (Hr1) repeat.
  Contains 1 SH3 domain.
• Cellular localization
  Cytoplasm. Cytoplasm > cytoskeleton. Cytoplasm > cell cortex. Lysosome. Cytoplasmic vesicle. Cell membrane. Enriched in cortical regions coincident with F-actin. Also localizes to endocytic vesicles and lysosomes.

• Target information above from: UniProt accession Q96RU3 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• Database links
  • Entrez Gene: 23048 Human
  • Entrez Gene: 14269 Mouse
  • Entrez Gene: 192348 Rat
  • Omim: 606191 Human
  • SwissProt: Q96RU3 Human
  • SwissProt: Q80TY0 Mouse
  • SwissProt: Q8R511 Rat
  • Unigene: 189409 Human

  • Unigene: 440993 Mouse
  • Unigene: 52297 Mouse
  • Unigene: 20445 Rat

  see all
• Alternative names
  • FBP1 antibody
  • FBP17 antibody
  • Fnbp1 antibody

  • FNBP1_HUMAN antibody
  • Formin binding protein 1 antibody
  • Formin binding protein 17 antibody
  • Formin-binding protein 1 antibody
  • Formin-binding protein 17 antibody
  • hFBP17 antibody
  • KIAA0554 antibody
  • MGC126804 antibody

  see all

Protocols

• Western blot protocols