• Product nameAnti-FBXL2 antibody
    See all FBXL2 primary antibodies
  • Description
    Rabbit polyclonal to FBXL2
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Horse, Chicken, Guinea pig, Cow, Cat, Dog, Zebrafish
  • Immunogen

    Synthetic peptide corresponding to a region within the N terminal amino acids 72-121 (ISKRCGGFLR KLSLRGCIGV GDSSLKTFAQ NCRNIEHLNL NGCTKITDST) of Human FBXL2 (NP_036289).

  • Positive control
    • Transfected 293T cell lysate


  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
  • Storage bufferPreservative: None
    Constituents: 2% Sucrose, PBS
  • Concentration information loading...
  • PurityImmunogen affinity purified
  • ClonalityPolyclonal
  • IsotypeIgG
  • Research areas


Our Abpromise guarantee covers the use of ab86545 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 47 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.


  • FunctionCalcium-activated substrate recognition component of a SCF (SKP1-cullin-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Unlike many F-box proteins, FBXL2 doesn't seem to target phosphodegron within its substrates but rather calmodulin-binding motifs. Targets PCYT1A for its monoubiquitination and degradation, this is antagonized by calmodulin (By similarity). Targets the cyclins CCND2 and CCND3 for polyubiquitination and degradation, leading to cell-cycle arrest in G(0), also antagonized by calmodulin. Binds to hepatitis C virus non-structural protein 5A (NS5A) in a reaction crucial for hepatitis C virus RNA replication.
  • Tissue specificityExpressed in brain, heart, kidney, liver, lung, pancreas and placenta.
  • Sequence similaritiesContains 1 F-box domain.
    Contains 13 LRR (leucine-rich) repeats.
  • Cellular localizationMembrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • DKFZP564P0622 antibody
    • F box and leucine rich repeat protein 2 antibody
    • F box protein containing leucine rich repeats antibody
    • F box protein FBL2/FBL3 antibody
    • F box/LRR repeat protein 2 antibody
    • F-box and leucine-rich repeat protein 2 antibody
    • F-box protein FBL2/FBL3 antibody
    • F-box/LRR-repeat protein 2 antibody
    • FBL 2 antibody
    • FBL 3 antibody
    • FBL2 antibody
    • FBL3 antibody
    • FBXL 2 antibody
    • FBXL2 antibody
    • FBXL2_HUMAN antibody
    see all

Anti-FBXL2 antibody images

  • Anti-FBXL2 antibody (ab86545) at 1 µg/ml (in 5% skim milk / PBS buffer) + transfected 293T cell lysate at 10 µg

    HRP conjugated anti-Rabbit IgG at 1/50000 dilution

    Predicted band size : 47 kDa
    Observed band size : 47 kDa
    Additional bands at : 28 kDa. We are unsure as to the identity of these extra bands.

References for Anti-FBXL2 antibody (ab86545)

ab86545 has not yet been referenced specifically in any publications.

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