Overview

  • Product nameAnti-FBXL20 antibody
    See all FBXL20 primary antibodies
  • Description
    Rabbit polyclonal to FBXL20
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Rabbit, Horse, Chicken, Guinea pig, Cow, Cat, Dog
  • Immunogen

    Synthetic peptide corresponding to a region within N terminal amino acids 110-159 (RTFAQNCRNI EVLNLNGCTK TTDATCTSLS KFCSKLRHLD LASCTSITNM) of Human FBXL20 (NP_116264).

  • Positive control
    • Human fetal brain lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab113803 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 48 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

Target

  • RelevanceFBXL20 is a member of the F-box protein family, which are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1, cullin, and F-box proteins, act as protein-ubiquitin ligases. FBXL20 is selectively expressed in the brain, broadly expressed within the mouse CNS and is abundant at presynaptic membrane. FBXL20 has orthologs in C. elegans, D. melanogaster, and mammals which suggests that it might function as an important membrane-localized E3 ligase in various species. FBXL20 is a major presynaptic E3 ubiquitin ligase that acts through RIM1a via degradation and the ubiquitin-proteasome-system (UPS) pathway to critically regulate synaptic transmission. This identifies protein degradation as a mechanism for holding synaptic communication in check.
  • Cellular localizationCytoplasmic
  • Database links
  • Alternative names
    • F box and leucine rich repeat protein 20 antibody
    • F box/LRR repeat protein 2 like antibody
    • F box/LRR repeat protein 20 antibody
    • Fbl2 antibody
    • Fbl20 antibody
    • MGC15482 antibody
    • SCR antibody
    • SCRAPPER antibody
    see all

Anti-FBXL20 antibody images

  • Anti-FBXL20 antibody (ab113803) at 1 µg/ml + Human fetal brain lysate at 10 µg

    Predicted band size : 48 kDa

References for Anti-FBXL20 antibody (ab113803)

ab113803 has not yet been referenced specifically in any publications.

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