Overview

  • Product name
  • Description
    Rabbit polyclonal to FBXO11
  • Tested applications
    Suitable for: WB, ELISA, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Synthetic peptide, derived from an internal sequence of FBXO11 (UniProt ID: Q86XK2).

Properties

Applications

Our Abpromise guarantee covers the use of ab110965 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/2000. Predicted molecular weight: 104 kDa.
ELISA Use at an assay dependent concentration.
IHC-P 1/100 - 1/1000.

Target

  • Function
    Substrate recognition component of the a (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. Binds to and neddylates phosphorylated p53/TP53, inhibiting its transcriptional activity. SCF(FBXO11) does not seem to direct ubiquitination of TP53.
  • Tissue specificity
    Isoform 5 is expressed in keratinocytes, fibroblasts and melanocytes.
  • Pathway
    Protein modification; protein ubiquitination.
  • Sequence similarities
    Contains 1 F-box domain.
    Contains 19 PbH1 repeats.
    Contains 1 UBR-type zinc finger.
  • Cellular localization
    Nucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • F box only protein 11 antibody
    • F box protein 11 antibody
    • F-box only protein 11 antibody
    • FBX11 antibody
    • FBX11_HUMAN antibody
    • Fbxo11 antibody
    • PRMT9 antibody
    • Protein arginine N methyltransferase 9 antibody
    • Ubiquitin protein ligase E3 component n recognin 6 antibody
    • UBR6 antibody
    • UG063H01 antibody
    • VIT 1 antibody
    • VIT-1 antibody
    • VIT1 antibody
    • Vitiligo associated protein 1 antibody
    • Vitiligo associated protein VIT 1 antibody
    • Vitiligo-associated protein 1 antibody
    see all

References

ab110965 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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