Overview

  • Product name
  • Description
    Rabbit polyclonal to FBXO11
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse
    Predicted to work with: Rat, Rabbit, Horse, Chicken, Guinea pig, Cat, Dog, Human, Drosophila melanogaster, Zebrafish
  • Immunogen

    Synthetic peptide corresponding to a region within C terminal amino acids 726-775 (RRNKIHDGRD GGICIFNGGR GLLEENDIFR NAQAGVLIST NSHPVLRKNR) of Mouse FBXO11 (NP_001074503).

  • Positive control
    • Mouse small intestine lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab125349 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 104 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

Target

  • Function
    Substrate recognition component of the a (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. Binds to and neddylates phosphorylated p53/TP53, inhibiting its transcriptional activity. SCF(FBXO11) does not seem to direct ubiquitination of TP53.
  • Tissue specificity
    Isoform 5 is expressed in keratinocytes, fibroblasts and melanocytes.
  • Pathway
    Protein modification; protein ubiquitination.
  • Sequence similarities
    Contains 1 F-box domain.
    Contains 19 PbH1 repeats.
    Contains 1 UBR-type zinc finger.
  • Cellular localization
    Nucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • F box only protein 11 antibody
    • F box protein 11 antibody
    • F-box only protein 11 antibody
    • FBX11 antibody
    • FBX11_HUMAN antibody
    • Fbxo11 antibody
    • PRMT9 antibody
    • Protein arginine N methyltransferase 9 antibody
    • Ubiquitin protein ligase E3 component n recognin 6 antibody
    • UBR6 antibody
    • UG063H01 antibody
    • VIT 1 antibody
    • VIT-1 antibody
    • VIT1 antibody
    • Vitiligo associated protein 1 antibody
    • Vitiligo associated protein VIT 1 antibody
    • Vitiligo-associated protein 1 antibody
    see all

Images

  • Anti-FBXO11 antibody (ab125349) at 1 µg/ml + Mouse small intestine lysate at 10 µg

    Secondary
    Goat anti-Rabbit IgG HRP

    Predicted band size : 104 kDa

References

ab125349 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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