Overview

  • Product nameAnti-FBXO11 antibody
    See all FBXO11 primary antibodies
  • Description
    Mouse monoclonal to FBXO11
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant fragment: KAVSRGQCLY KISSYTSYPM HDFYRCHTCN TTDRNAICVN CIKKCHQGHD VEFIRHDRFF CDCGAGTLSN PCTLAGEPTH DTDTLYDSAP PIESNTLQHN , corresponding to amino acids 744-844 of Human FBXO11

Properties

Applications

Our Abpromise guarantee covers the use of ab57812 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
  • Application notesWB: Use at a concentration of 1-5 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionSubstrate recognition component of the a (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. Binds to and neddylates phosphorylated p53/TP53, inhibiting its transcriptional activity. SCF(FBXO11) does not seem to direct ubiquitination of TP53.
    • Tissue specificityIsoform 5 is expressed in keratinocytes, fibroblasts and melanocytes.
    • PathwayProtein modification; protein ubiquitination.
    • Sequence similaritiesContains 1 F-box domain.
      Contains 19 PbH1 repeats.
      Contains 1 UBR-type zinc finger.
    • Cellular localizationNucleus.
    • Information by UniProt
    • Database links
    • Alternative names
      • F box protein 11 antibody
      • F-box only protein 11 antibody
      • FBX11 antibody
      • FBX11_HUMAN antibody
      • Fbxo11 antibody
      • PRMT9 antibody
      • Protein arginine N methyltransferase 9 antibody
      • Ubiquitin protein ligase E3 component n recognin 6 antibody
      • UBR6 antibody
      • UG063H01 antibody
      • VIT-1 antibody
      • VIT1 antibody
      • Vitiligo associated protein VIT 1 antibody
      • Vitiligo-associated protein 1 antibody
      see all

    Anti-FBXO11 antibody images

    • Western blot against tagged recombinant protein immunogen using ab57812 FBXO11 antibody at 1ug/ml. Predicted band size of immunogen is 37 kDa

    References for Anti-FBXO11 antibody (ab57812)

    ab57812 has not yet been referenced specifically in any publications.

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