Overview

  • Product name
  • Description
    Mouse polyclonal to FbxO6
  • Host species
    Mouse
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Full length protein corresponding to Human FbxO6 aa 1-293. (NP_060908.1)
    Sequence:

    MDAPHSKAALDSINELPENILLELFTHVPARQLLLNCRLVCSLWRDLIDL MTLWKRKCLREGFITKDWDQPVADWKIFYFLRSLHRNLLRNPCAEEDMFA WQIDFNGGDRWKVESLPGAHGTDFPDPKVKKYFVTSYEMCLKSQLVDLVA EGYWEELLDTFRPDIVVKDWFAARADCGCTYQLKVQLASADYFVLASFEP PPVTIQQWNNATWTEVSYTFSDYPRGVRYILFQHGGRDTQYWAGWYGPRV TNSSIVVSPKMTRNQASSEAQPGQKHGQEEAAQSPYRAVVQIF


    Database link: Q9NRD1

  • Positive control
    • FbxO6-transfected 293T cell lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab172492 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Predicted molecular weight: 34 kDa.

Target

  • Function
    Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complexes. Involved in endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranlocated into the cytosol and promoting their ubiquitination and subsequent degradation. Able to recognize and bind denatured glycoproteins, which are modified with not only high-mannose but also complex-type oligosaccharides. Also recognizes sulfated glycans. Also involved in DNA damage response by specifically recognizing activated CHEK1 (phosphorylated on 'Ser-345'), promoting its ubiquitination and degradation. Ubiquitination of CHEK1 is required to insure that activated CHEK1 does not accumulate as cells progress through S phase, or when replication forks encounter transient impediments during normal DNA replication.
  • Pathway
    Protein modification; protein ubiquitination.
  • Sequence similarities
    Contains 1 F-box domain.
    Contains 1 FBA (F-box associated) domain.
  • Cellular localization
    Cytoplasm.
  • Information by UniProt
  • Database links
  • Alternative names
    • F box protein that recognizes sugar chains 2 antibody
    • F box G domain protein 2 antibody
    • F box only protein 6 antibody
    • F box protein 6 antibody
    • F box protein FBG2 antibody
    • F box protein Fbx6 antibody
    • F box/G domain protein 2 antibody
    • F-box only protein 6 antibody
    • F-box protein that recognizes sugar chains 2 antibody
    • F-box/G-domain protein 2 antibody
    • FBG 2 antibody
    • FBG2 antibody
    • FBS 2 antibody
    • FBS2 antibody
    • FBX 6 antibody
    • FBX6 antibody
    • FBX6_HUMAN antibody
    • FBXO 6 antibody
    • FBXO6 antibody
    • OTTHUMP00000002267 antibody
    see all

Images

  • All lanes : Anti-FbxO6 antibody (ab172492) at 1/500 dilution

    Lane 1 : FbxO6-transfected 293T cell lysate
    Lane 2 : Non-transfected 293T cell lysate

    Lysates/proteins at 15 µl per lane.

    Developed using the ECL technique.

    Predicted band size: 34 kDa

References

ab172492 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab172492.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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