Anti-Fbxw7 antibody (ab84783)
Key features and details
- Rabbit polyclonal to Fbxw7
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-Fbxw7 antibody
See all Fbxw7 primary antibodies -
Description
Rabbit polyclonal to Fbxw7 -
Host species
Rabbit -
Tested applications
Suitable for: IHC-Pmore details -
Species reactivity
Reacts with: Human
Predicted to work with: Chimpanzee, Rhesus monkey, Gorilla -
Immunogen
Synthetic peptide corresponding to a region aithin amino acids 50 - 100 of Human Fbxw7 (NP_361014.1)
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Positive control
- Breast carcinoma, O=ovarian carcinoma, pancreatic islet cell tumor, skin melanoma, small cell lung cancer.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
Storage buffer
pH: 6.8
Preservative: 0.09% Sodium azide
Constituents: Tris buffered saline, 0.1% BSA -
Concentration information loading...
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Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab84783 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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IHC-P |
Notes |
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Note: expected to work on frozen sections.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
Target
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Function
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. Involved in the degradation of cyclin-E, MYC, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1. -
Tissue specificity
Isoform 1 is widely expressed. Isoform 4 is expressed in brain. -
Sequence similarities
Contains 1 F-box domain.
Contains 7 WD repeats. -
Post-translational
modificationsPhosphorylated upon DNA damage, probably by ATM or ATR. -
Cellular localization
Cytoplasm; Nucleus; Nucleus > nucleolus and Nucleus > nucleoplasm. - Information by UniProt
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Database links
- Entrez Gene: 55294 Human
- Omim: 606278 Human
- SwissProt: Q969H0 Human
- Unigene: 561245 Human
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Alternative names
- AGO antibody
- Archipelago antibody
- Archipelago homolog antibody
see all
Images
Datasheets and documents
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SDS download
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Datasheet download
References (2)
ab84783 has been referenced in 2 publications.
- Liu H et al. Low expression of the ubiquitin ligase FBXW7 correlates with poor prognosis of patients with colorectal cancer. Int J Clin Exp Pathol 11:413-419 (2018). PubMed: 31938126
- Imura S et al. Role of Fbxw7 expression in hepatocellular carcinoma and adjacent non-tumor liver tissue. J Gastroenterol Hepatol 29:1822-9 (2014). PubMed: 24731221