Overview

  • Product name
  • Description
    Rabbit polyclonal to FCRL3
  • Tested applications
    Suitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    antigen, corresponding to amino acids 602-725 of Human FCRL3.

  • Positive control
    • Human cerebral cortex tissue.

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
  • Storage buffer
    pH: 7.20
    Preservative: 0.02% Sodium azide
    Constituents: 59% PBS, 40% Glycerol
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab121471 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/20 - 1/50. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • Tissue specificity
    Primarily expressed in secondary lymphoid tissues by mature subsets of B cells. Detected in spleen, lymph node, peripheral blood lymphocytes, thymus, bone marrow, kidney, salivary gland, adrenal gland and uterus. Expressed a low levels in naive, germinal center and memory B cells but also expressed in NK cells (at protein level).
  • Involvement in disease
    Genetic variation in FCRL3 may be a cause of susceptibility to rheumatoid arthritis (RA) [MIM:180300]. It is a systemic inflammatory disease with autoimmune features and a complex genetic component. It primarily affects the joints and is characterized by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures.
    Genetic variation in FCRL3 may influence susceptibility to Graves disease, an autoimmune disorder associated with overactivity of the thyroid gland and hyperthyroidism.
  • Sequence similarities
    Contains 6 Ig-like C2-type (immunoglobulin-like) domains.
  • Post-translational
    modifications
    Phosphorylated on cytoplasmic tyrosines; required for interaction with protein tyrosine phosphatases and protein tyrosine kinases.
  • Cellular localization
    Cell membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • CD307c antibody
    • Fc receptor homolog 3 antibody
    • Fc receptor-like protein 3 antibody
    • FcR-like protein 3 antibody
    • FcRH3 antibody
    • FcRL3 antibody
    • FCRL3_HUMAN antibody
    • hIFGP3 antibody
    • IFGP family protein 3 antibody
    • IFGP3 antibody
    • Immune receptor translocation-associated protein 3 antibody
    • Immunoglobulin superfamily receptor translocation associated protein 3 antibody
    • IRTA3 antibody
    • SH2 domain-containing phosphatase anchor protein 2 antibody
    • SPAP2 antibody
    see all

Anti-FCRL3 antibody images

  • ab121471, at 1/20 dilution, staining FCRL3 in paraffin-embedded Human cerebral cortex tissue, by Immunohistochemistry.

References for Anti-FCRL3 antibody (ab121471)

ab121471 has not yet been referenced specifically in any publications.

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