Overview

  • Product name
  • Description
    Rabbit polyclonal to FECH
  • Host species
    Rabbit
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Cow, Pig, Xenopus laevis
  • Immunogen

    Recombinant fragment, corresponding to a region within amino acids 129-370 of Human FECH.

  • Positive control
    • HeLa and HepG2 cell lysates.

Properties

Applications

Our Abpromise guarantee covers the use of ab153801 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 48 kDa.

Target

  • Function
    Catalyzes the ferrous insertion into protoporphyrin IX.
  • Pathway
    Porphyrin metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1.
  • Involvement in disease
    Erythropoietic protoporphyria (EPP) [MIM:177000]: A form of porphyria. Porphyrias are inherited defects in the biosynthesis of heme, resulting in the accumulation and increased excretion of porphyrins or porphyrin precursors. They are classified as erythropoietic or hepatic, depending on whether the enzyme deficiency occurs in red blood cells or in the liver. Erythropoietic protoporphyria is marked by excessive protoporphyrin in erythrocytes, plasma, liver and feces, and by widely varying photosensitive skin changes ranging from a burning or pruritic sensation to erythema, edema and wheals. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Sequence similarities
    Belongs to the ferrochelatase family.
  • Cellular localization
    Mitochondrion inner membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • EPP antibody
    • FCE antibody
    • Fch antibody
    • Fcl antibody
    • fech antibody
    • Ferrochelatase (protoporphyria) antibody
    • Ferrochelatase antibody
    • Ferrochelatase mitochondrial antibody
    • Heme synthase antibody
    • Heme synthetase antibody
    • HEMH_HUMAN antibody
    • mitochondrial antibody
    • Protoheme ferro lyase antibody
    • Protoheme ferro-lyase antibody
    • Protoporphyria antibody
    see all

Images

  • Anti-FECH antibody (ab153801) at 1/1000 dilution + HeLa whole cell
    lysate at 30 µg

    Predicted band size: 48 kDa



    10% SDS PAGE

References

ab153801 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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