Overview

  • Product nameAnti-FECH antibody
    See all FECH primary antibodies
  • Description
    Mouse polyclonal to FECH
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Full length Human FECH protein (NP_000131.2, amino acids 1-423).

  • Positive control
    • Human liver tissue lysate. FECH transfected 293T cell lysate.

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab88838 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Predicted molecular weight: 48 kDa.

Target

  • FunctionCatalyzes the ferrous insertion into protoporphyrin IX.
  • PathwayPorphyrin metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1.
  • Involvement in diseaseErythropoietic protoporphyria (EPP) [MIM:177000]: A form of porphyria. Porphyrias are inherited defects in the biosynthesis of heme, resulting in the accumulation and increased excretion of porphyrins or porphyrin precursors. They are classified as erythropoietic or hepatic, depending on whether the enzyme deficiency occurs in red blood cells or in the liver. Erythropoietic protoporphyria is marked by excessive protoporphyrin in erythrocytes, plasma, liver and feces, and by widely varying photosensitive skin changes ranging from a burning or pruritic sensation to erythema, edema and wheals. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Sequence similaritiesBelongs to the ferrochelatase family.
  • Cellular localizationMitochondrion inner membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • EPP antibody
    • FCE antibody
    • Fch antibody
    • Fcl antibody
    • fech antibody
    • Ferrochelatase (protoporphyria) antibody
    • Ferrochelatase antibody
    • Ferrochelatase mitochondrial antibody
    • Heme synthase antibody
    • Heme synthetase antibody
    • HEMH_HUMAN antibody
    • mitochondrial antibody
    • Protoheme ferro lyase antibody
    • Protoheme ferro-lyase antibody
    • Protoporphyria antibody
    see all

Anti-FECH antibody images

  • Anti-FECH antibody (ab88838) at 1/500 dilution + human liver tissue lysate at 50 µg

    Predicted band size : 48 kDa
    Observed band size : 40 kDa (why is the actual band size different from the predicted?)
  • All lanes : Anti-FECH antibody (ab88838) at 1/500 dilution

    Lane 1 : FECH transfected 293T cell lysate
    Lane 2 : Non transfected 293T cell lysate

    Lysates/proteins at 25 µg per lane.


    Predicted band size : 48 kDa
    Observed band size : 46 kDa (why is the actual band size different from the predicted?)

References for Anti-FECH antibody (ab88838)

ab88838 has not yet been referenced specifically in any publications.

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