Overview

Description

  • Nature
    Synthetic

Associated products

Specifications

Our Abpromise guarantee covers the use of ab6098 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking

  • Form
    Liquid
  • Additional notes

    Stable for one year.

    F1A alpha, also termed FEM1 beta, is a novel protein that associates with the intracellular domains of Fas and TNFR1. Over expression of F1A alpha induces apoptosis. F1A alpha also associates with CED-4 and its mammalian homologue Apaf-1, and can be cleaved by CED-3 and caspases.

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Preservative: 0.02% Sodium Azide
    Constituents: 0.1% BSA, PBS, pH 7.2

General Info

  • Alternative names
    • F1A alpha
    • F1A-alpha
    • F1AA
    • Fem-1-like death receptor-binding protein alpha
    • Fem-1-like in apoptotic pathway protein alpha
    • Fem1 homolog b
    • FEM1 like death receptor binding protein
    • FEM1-beta
    • FEM1b
    • FEM1B_HUMAN
    • Protein fem-1 homolog B
    see all
  • Function
    Component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit. Involved in apoptosis by acting as a death receptor-associated protein that mediates apoptosis. Also involved in glucose homeostasis in pancreatic islet. Functions as an adapter/mediator in replication stress-induced signaling that leads to the activation of CHEK1.
  • Tissue specificity
    Widely expressed. Highly expressed in testis. Weakly expressed in other tissues.
  • Pathway
    Protein modification; protein ubiquitination.
  • Sequence similarities
    Belongs to the fem-1 family.
    Contains 8 ANK repeats.
    Contains 1 TPR repeat.
  • Cellular localization
    Cytoplasm. Nucleus. In the nucleus, the protein level increased slightly after camptothecin (CPT) treatment. Associated with chromatin.
  • Information by UniProt

References

ab6098 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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