The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Stable for one year.
F1A alpha, also termed FEM1 beta, is a novel protein that associates with the intracellular domains of Fas and TNFR1. Over expression of F1A alpha induces apoptosis. F1A alpha also associates with CED-4 and its mammalian homologue Apaf-1, and can be cleaved by CED-3 and caspases.
Concentration information loading...
Preparation and Storage
Stability and Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
FunctionComponent of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit. Involved in apoptosis by acting as a death receptor-associated protein that mediates apoptosis. Also involved in glucose homeostasis in pancreatic islet. Functions as an adapter/mediator in replication stress-induced signaling that leads to the activation of CHEK1.
Tissue specificityWidely expressed. Highly expressed in testis. Weakly expressed in other tissues.
PathwayProtein modification; protein ubiquitination.
Sequence similaritiesBelongs to the fem-1 family. Contains 8 ANK repeats. Contains 1 TPR repeat.
Cellular localizationCytoplasm. Nucleus. In the nucleus, the protein level increased slightly after camptothecin (CPT) treatment. Associated with chromatin.