The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use a concentration of 1 - 5 µg/ml. Predicted molecular weight: 74 kDa.
FunctionProbable component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit (By similarity). May participate in antiinflammatory signaling via its interaction with PTGER4.
Tissue specificityPresent in macrophages derived from peripheral blood monocytes. Also present in atheromata (at protein level).
PathwayProtein modification; protein ubiquitination.
Sequence similaritiesBelongs to the fem-1 family. Contains 9 ANK repeats. Contains 2 TPR repeats.