Anti-Ferritin Light Chain antibody (ab110017)

Overview

  • Product name
    Anti-Ferritin Light Chain antibody
    See all Ferritin Light Chain primary antibodies
  • Description
    Goat polyclonal to Ferritin Light Chain
  • Tested applications
    Suitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Rabbit, Horse, Guinea pig, Cow, Cat, Dog, Pig
  • Immunogen

    Synthetic peptide:

    C-GEYLFERLTLKHD

    , corresponding to C terminal amino acids 163-175 of Human Ferritin Light Chain

  • Positive control
    • Human brain (cortex) tissue, Human kidney tissue, Human placenta lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab110017 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.1 - 0.3 µg/ml. Predicted molecular weight: 20 kDa.
IHC-P Use a concentration of 3.75 µg/ml.

Target

  • Function
    Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney.
  • Involvement in disease
    Defects in FTL are the cause of hereditary hyperferritinemia-cataract syndrome (HHCS) [MIM:600886]. It is an autosomal dominant disease characterized by early-onset bilateral cataract. Affected patients have elevated level of circulating ferritin. HHCS is caused by mutations in the iron responsive element (IRE) of the FTL gene.
    Defects in FTL are the cause of neurodegeneration with brain iron accumulation type 3 (NBIA3) [MIM:606159]; also known as adult-onset basal ganglia disease. It is a movement disorder with heterogeneous presentations starting in the fourth to sixth decade. It is characterized by a variety of neurological signs including parkinsonism, ataxia, corticospinal signs, mild nonprogressive cognitive deficit and episodic psychosis. It is linked with decreased serum ferritin levels.
  • Sequence similarities
    Belongs to the ferritin family.
    Contains 1 ferritin-like diiron domain.
  • Information by UniProt
  • Database links
  • Alternative names
    • Ferritin L chain antibody
    • Ferritin L subunit antibody
    • Ferritin light chain antibody
    • Ferritin light polypeptide antibody
    • ferritin light polypeptide like 3 antibody
    • FRIL_HUMAN antibody
    • FTL antibody
    • LFTD antibody
    • NBIA 3 antibody
    • NBIA3 antibody
    see all

Anti-Ferritin Light Chain antibody images

  • ab110017, at 3.75 µg/ml, staining Ferritin Light Chain in Human brain (cortex) by immunohistochemistry.
  • ab110017, at 3.75 µg/ml, staining Ferritin Light Chain in Human kidney tissue by immunohistochemistry.
  • Anti-Ferritin Light Chain antibody (ab110017) at 0.1 µg/ml + Human placenta lysate at 35 µg

    Predicted band size : 20 kDa

References for Anti-Ferritin Light Chain antibody (ab110017)

ab110017 has not yet been referenced specifically in any publications.

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